Process for preparing vaccine adjuvant
Chemically modified endotoxin immunizing agent
6,6'-Diesters of trehalose and process for the synthesis thereof
1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases
Collectors of solar energy trapping devices
Refined detoxified endotoxin product
Polyoxypropylene-polyoxyethylene block polymer based adjuvants Patent #: 4606918
ApplicationNo. 06/852118 filed on 04/15/1986
US Classes:424/282.1, Bacterium or component thereof or substance produced by said bacterium424/244.1, Streptococcus (e.g., Group B Streptococcus, pneumococcus or Streptococcus pneumoniae, etc.)424/283.1, Lipid or oil514/21, Produced by or extracted from animal tissue514/885, IMMUNE RESPONSE AFFECTING DRUG514/937DISPERSION OR EMULSION
ExaminersPrimary: Thexton, Matthew A.
Assistant: Kilby, Catherine S.
Attorney, Agent or Firm
International ClassA61K 39/39 (20060101)
AbstractAn immunological adjuvant for polysaccharide vaccines is provided whereby polysaccharide antigens are rendered more immunogenic and thus stimulate more antibody production including an IgG response and immunological memory. The adjuvant is comprised of (1) either (A) an emulsion system containing a metabolizable oil, a low molecular weight polyol and lecithin, or (B) an oil-in-water emulsion system containing a light hydrocarbon non-biodegradable oil or a biodegradable oil, and a detergent; and (2) a refined detoxified endotoxin. The adjuvant can optionally also contain trehalose dimycolate.