Device for pH independent release of drugs through the Donnan-like influence of charged insoluble resins
August 3, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2846057 2928770 3538214 Coating compositions for solid medicines Microporous drug delivery device Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina Osmotic system with distribution zone for dispensing beneficial agent System with microporous reservoir having surface for diffusional delivery of agent Prolonged release pharmaceutical preparations Device for dispensing drug by combined diffusional and osmotic operations InventorAssigneeApplicationNo. 07/081090 filed on 08/03/1987US Classes:424/468, Sustained or differential release type424/457, Sustained or differential release424/474, Coated pills or tablets424/482Containing solid synthetic polymersExaminersPrimary: Page, Thurman K.Assistant: Horne, Leon R. Attorney, Agent or FirmInternational ClassA61K 9/00 (20060101)AbstractA device is disclosed for the controlled delivery of a beneficial agent. The agent is delivered to the environment surrounding the device at a substantially constant rate for a specified period with a reduced dependence on the environmental pH. The device is comprised of a core compartment containing (1) a charged, water insoluble, non-diffusible component and (2) at least one diffusable water soluble ionizable beneficial agent. The core is surrounded by a water insoluble wall containing leachable pore forming additive(s) dispersed throughout said wall, with said wall impermeable to core components (1) and permeable to beneficial agent(s) (2). In operation the insoluble charged component (often polymeric resins) and water soluble ionizable beneficial agent have the same electro-static charge and do not form an ion exchange complex. Rather, a Donnan influenced mass transport phenomena of the beneficial agent is effected through the pores in the device, actuated by water from the environment, with migration of the freely mobile diffusible species (beneficial agent) away from the non-mobile species (charged entity). This effects the release of the beneficial agent through the wall at a controlled rate with reduced pH dependency.Other References
Field of SearchDiscrete particles in supporting matrixContaining discrete coated particles pellets, granules, or beads With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.) Printed, embossed, grooved, or perforated Specially adapted for ruminant animal With claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.) Telescoping two piece Gelatin With tamperproof, locking, or sealing feature Containing emulsions, dispersions, or solutions Sustained or differential release Depot, pellet, matrix, or suppository Sustained or differential release type Cellulose or derivative Bioerrodable, resorbable, or dissolving | |
