Method for contraception by immunization against the zona pellucida

Patent 4795634 Issued on January 3, 1989. Estimated Expiration Date:

March 14, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Anti-fertility vaccine comprising solubilized zona pellucida and anti-serum
Patent #: 3992520
Issued on: 11/16/1976
Inventor: Gwatkin

Reproduction control
Patent #: 4248864
Issued on: 02/03/1981
Inventor: Jones

Contraceptive agent
Patent #: 4297343
Issued on: 10/27/1981
Inventor: Bohn , et al.

Antigenic modification of polypeptides
Patent #: 4526716
Issued on: 07/02/1985
Inventor: Stevens

Monoclonal anti-idiotype antibodies
Patent #: 4661586
Issued on: 04/28/1987
Inventor: Levy , et al.

Method of producing monoclonal anti-idiotype antibody Patent #: 4699880
Issued on: 10/13/1987
Inventor: Goldstein

Inventors

Assignee

Aphton Corporation

Application

No. 06/839894 filed on 03/14/1986

US Classes:

424/131.1, Anti-idiotypic424/152.1, Binds eukaryotic cell or component thereof or substance produced by said eukaryotic cell424/172.1, Binds eukaryotic cell or component thereof or substance produced by said eukaryotic cell (e.g., honey, etc.)424/811, INVOLVING SEX SELECTION OR CONTRACEPTION530/387.2, Anti-idiotypic530/388.1, Monoclonal530/388.2, Binds microorganism or normal or mutant component or product thereof (e.g., animal cell, cell-surface antigen, secretory product, etc.)530/389.1, Polyclonal antibody or immunogloblin of identified binding specificity530/861, INVOLVING IGG3, IGG4, IGA, OR IGY530/864Monoclonal

Examiners

Primary: Schain, Howard E.

Attorney, Agent or Firm

International Classes

C07K 16/18 (20060101)
C07K 16/42 (20060101)
C07K 16/28 (20060101)

Abstract

This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies, which anti-idiotypic antibodies express internal images of zona pellucida antigenic determinants capable of eliciting a contraceptive response.