U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants

Patent 4795327 Issued on January 3, 1989. Estimated Expiration Date: Icon_subject January 3, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Sustained release pharmaceutical composition
Patent #: 4138475
Issued on: 02/06/1979
Inventor: McAinsh ,   et al.

Prolonged-release pharmaceutical compositions for oral administration, their methods of making and use
Patent #: 4155993
Issued on: 05/22/1979
Inventor: Belleville ,   et al.

Method and composition for the preparation of controlled long-acting pharmaceuticals
Patent #: 4259314
Issued on: 03/31/1981
Inventor: Lowey

Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
Patent #: 4369172
Issued on: 01/18/1983
Inventor: Schor ,   et al.

Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
Patent #: 4389393
Issued on: 06/21/1983
Inventor: Schor ,   et al.

Sustained release pharmaceutical composition of solid medical material Patent #: 4404183
Issued on: 09/13/1983
Inventor: Kawata ,   et al.

Inventors

Application

No. 06/592570 filed on 03/26/1984

US Classes:

424/468, Sustained or differential release type424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/494Cellulose derivatives

Examiners

Primary: Schenkman, Leonard

Attorney, Agent or Firm

International Class

A61K 9/20 (20060101)

Abstract

A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and prolonged release pattern upon administration, the carrier base material being a mixture of one or more nonionic cellulose ethers and an anionic surfactant, and wherein at least one of the cellulose ethers is methyl cellulose or hydroxypropylmethylcellulose having a number average molecular weight of at least 50,000.

Other References

  • Daly "Effect of Anionic Surfactants on the Release of Chlorpheniramnine from a Polymer Matrix Tablet" Int. J. Pharm. 18 (1984) 201-205
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