Formulations providing three distinct releases
Patent 4794001 Issued on December 27, 1988. Estimated Expiration Date: 
September 24, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 24, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesInventorsAssigneeApplicationNo. 07/100646 filed on 09/24/1987US Classes:424/458, Containing discrete coated particles pellets, granules, or beads424/453, Telescoping two piece424/457, Sustained or differential release424/459, Organic coatings424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462Containing solid synthetic polymersExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassA61K 9/50 (20060101)AbstractA therapeutic preparation consisting of three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance a second group of spheroids is coated with a pH sensitive coat to provide a second dose and a third group of spheroids is coated with a pH independent coat to provide a third dose. A powder blend of active medicinal substance may be substituted for the first group of uncoated spheroids.The therapeutic preparation may be utilized as a mixture of groups of spheroids in a capsule.Other References
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