U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Anticonvulsant phenethyl sulfamates

Patent 4792569 Issued on December 20, 1988. Estimated Expiration Date: Icon_subject August 27, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3058981

3840579

Inhibition of male fertility with aliphatic sulfamates
Patent #: 4075351
Issued on: 02/21/1978
Inventor: Hirsch

Anticonvulsant sulfamate derivatives
Patent #: 4513006
Issued on: 04/23/1985
Inventor: Maryanoff ,   et al.

Anticonvulsant dioxolane methane sulfamates Patent #: 4591601
Issued on: 05/27/1986
Inventor: Maryanoff ,   et al.

Inventors

Application

No. 07/089880 filed on 08/27/1987

US Classes:

514/517, S-X-C containing (e.g., sulfates, etc.) (X is chalcogen)558/48, Nitrogen attached directly or indirectly to the sulfonate group by acyclic nonionic bonding558/53Halogen attached directly or indirectly to the sulfonate group by acyclic nonionic bonding

Examiners

Primary: Chan, Nicky

Attorney, Agent or Firm

International Classes

C07C 307/00 (20060101)
C07C 307/02 (20060101)
A61K 31/21 (20060101)
A61K 31/255 (20060101)

Abstract

Sulfamates of the following formula (I) are anticonvulsants and are useful in the treatment of epilepsy: ##STR1## wherein R is one or more substituents such as alkyl, halo, alkoxy, CH3 or nitro; andx is 0-3.

Other References

  • N K. Kochetkov et al., in Zhurnal Obshchei Khimii, vol. 41, No. 8, pp. 1866-1871, (1971)
  • N. K. Kochetkov et al., in Journal of General Chemistry of the USSR 42 (12) 2755-57 (1972)
  • N. K. Kochetkov et al., in Journal of General Chemistry of the USSR 44(4) 871-875 (1974)
  • N. K. Kochetkov et al., in Doklady Akademii Nauk SSSR, vol. 216, No. 1, pp. 97-100, (1974)
  • Tetrahedron Letters No. 36, pp. 3365-3368, Pergamon Press Ltd. (1978) ty T. Tsuchiya
  • J. Med. Chem. 1981, 24, 901-903, A. F. Hirsch
  • J. Med. Chem. 1987, 30, 880-887, B. E. Maryanoff et al
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