Patent 4790305 Issued on December 13, 1988. Estimated Expiration Date: June 23, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Apparatus for use in inhaling pharmaceutical aerosols. The apparatus comprises a mouthpiece for supplying a pharmaceutical composition to the mouth of a patient, a rigid chamber for holding the aerosol prior to inhalation, the rigid chamber having orifices to limit the flow of air therethrough, and a collapsable chamber from which the patient inhales unmedicated air prior to inhaling the medicated air from the rigid chamber. The apparatus increases medication delivered to the small peripheral bronchi, while it limits deposition in the oropharynx. The patient is aided in inhaling a volume of unmedicated air, after which he automatically begins to receive the aerosolized medication with the inhaled air. The volumetric flow rate of the inhaled medication is kept below required limits for optimal dosing.
Other References
Laros et al., "Absorption, Distribution and Excretion of the Tritium-Labelled ଲ2 Stimulator Fenoterol Hydrobromide Following Aerosol Administration and Instillation Into the Bronchial Tree", Respiration, vol. 131, p. 140 (1977)
Newman et al., "How Should a Pressurized ଲ-Adrenergic Bronchodilator be Inhaled?," Eur. J. Respir. Dis., vol. 62, pp. 3-21, (1981)
Heimer et al., "The Effect of Sequential Inhalations of Metaproterenol Aerosol in Asthma", J. Allergy Clin. Immunol., vol. 66, No. 1, pp. 75-77, (1980)
Bell et al., "Variation in Delivery of Isoprenaline From Various Pressurized Inhalers" J. Pharm. Pharmac., vol. 25, Suppl., pp. 32-36, (1973)
Godden et al., "An objective Assessment of the Tube Spacer in Patients Unable to Use a Conventional Pressurized Aerosol Efficiently", Br. J. Dis. Chest, vol. 75, pp. 165-168, (1981)
Moven, "Drug Deposition of Pressurized Inhalation Aerosols", I. Influence of Actuator Tube Design, International Journal of Pharmaceutics, vol. 1, pp. 205-212, (1978)
"The Proper Use of Aerosol Bronchodilators", The Lancet, pp. 23-24, Jan. 3, 1981
Gayrard et al., "Mauvaise Utilisation, des Aerosol-Doseurs par les Asthmatiques", Respiration, vol. 40, pp. 47-52, (1980)
Gumm et al., "Effect of an Extension Tube on the Bronchodilator Efficacy of Terbutaline Delivered from a Metered Dose Inhaler", Thorax, vol. 35, pp. 552-556, (1980)
Popa, "How to Inhale a Whiff of Pressurized Bronchodilator," Chest, vol. 76, pp. 496-498, (1979)
Freigang, "New Method of Beclomethasone Aerosol Administration to Children Under 4 Years of Age", CMA Journal, vol. 117, pp. 1308-1309, Dec. 3, 1977
Shim et al., "The Adequacy of Inhalation of Aerosol from Canister Nebulizers", The American Journal of Medicine, vol. 69, pp. 891-894 (1980)
Neuman et al., "Simple Instructions for Using Pressurized Aerosol Bronchodilators," Journal of the Royal Society of Medicine, vol 73, pp. 776-779, (1980)
Ellul-Micallef et al., "Use of a Special Inhaler Attachment in Asthmatic Children", Thorax, vol. 35, pp. 620-623, (1980)
Neuman et al., "Deposition of Pressurised Aerosols in the Human Respiratory Tract", Thorax, vol. 36, pp. 52-55, (1981)
Poppius, "Inhalation of Terbutaline Spray Through an Extended Mouthpiece", Respiration, vol. 40, pp. 278-283, (1980)
Orehek et al., "Patient Error in Use of Bronchodilator Metered Aerosols", British Medical Journal, vol. 10, p. 76, (1976)
Graf et al., "Use of Pressurized Aerosols by Asthmatic Patients", British Medical Journal, vol. 10, pp. 76-77
Woodcock, "Training Aid for Pressurized Inhalers", Br. J. Dis. Chest, vol. 74, pp. 395-397, (1980)
Lindgren et al., "Improved Aerosol Therapy of Asthma: Effect of Actuator Tube Size on Drug Availability," Eur. J. Respir. Dis., vol. 61, pp. 56-61, (1980)
Greico, "In Vivo Comparison of Triamcinolone and Beclomethasone Inhalation Delivery Systems", Annals of Allergy, vol. 45, pp. 231-234 (1980)
June 23, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
