Analytical device and method utilizing a piezoelectric crystal biosensor
Patent 4789804 Issued on December 6, 1988. Estimated Expiration Date: 
September 17, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 17, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3200271 3260104 3266291 3343044 3561253 3879992 Protein immobilizer Method for the assay of classes of antigen-specific antibodies Immunoassay for antigens Method of detecting adherent cells InventorsAssigneeApplicationNo. 06/908371 filed on 09/17/1986US Classes:310/311, Piezoelectric elements and devices310/321, Combined with resonant structure310/328, With mechanical energy coupling means422/55, Structured visual or optical indicator, per se422/57, Having coated reagent435/29, Involving viable micro-organism435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP436/827, LECTINS436/828, PROTEIN A436/829, LIPOSOMES (E.G., ENCAPSULATION, ETC.)73/61.79By vibrationExaminersPrimary: Budd, Mark O.Attorney, Agent or FirmInternational ClassesG01N 27/00 (20060101)G01N 33/543 (20060101) Foreign Application Priority Data1985-09-17 JPAbstractA bio-sensor is mounted in a container and comprised of a receptor for selectively reacting with a specific biochemical substance in a sample liquid held in the container to bind thereon the specific biochemical substance and a resonator integrated with the receptor for detecting the amount of the specific biochemical substance bound to the receptor in terms of a resonant frequency shift of the resonator. A measuring circuit is connected to the sensor for measuring the resonant frequency shift of the resonator within the container; a switching valve operates during the reaction of the receptor with the specific biochemical substance to charge a sample liquid into the container to contact the sample liquid with the receptor to thereby effect the reaction and operates during the measurement of the resonant frequency shift to replace the sample liquid by a buffer liquid in the container to immerse the sensor in the buffer liquid to thereby prevent a fluctuation of the resonant frequency shift. |
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