Method for eliciting anxiolysis

Patent 4786647 Issued on November 22, 1988. Estimated Expiration Date:

June 30, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Inventors

Assignee

University of Florida

Application

No. 06/879944 filed on 06/30/1986

US Classes:

514/355At 3-position

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Classes

C07D 211/00 (20060101)
C07D 211/90 (20060101)
A61K 31/44 (20060101)

Abstract

The invention provides a method for relieving anxiety in a mammal using a compound of the formula ##STR1## wherein R is Benzyl or cyclohexyl, or a non-toxic pharmaceutically acceptable salt thereof. A preferred compound for use in the subject method is 1-methyl-3-{N-[(3'-benzyloxycarbonyl)propyl]}carbamoyl-1,4-dihydropyridine .

Other References

Chem. Abst. 96-193953(b) (1982)
Chem. Abst. 104-122325(w) (1986)
Goodman and Gilman's The Pharmacological Basis of Therapeutics, Sixth Edition, ed. A. G. Gilman et al, MacMillan Publishing Co., Inc., New York 1980, Chapter 19, pp. 436-447
D. J. Sanger et al, in L.E.R.S., vol. 4, ed. G. Bartholini et al, Raven Press, New York, 1986, pp. 77-84
M. G. Corda et al, in GABAergic Transmission and Anxiety, ed. G. Biggio et al, Raven Press, New York, 1986, pp. 121-136
J.-Y. Wu et al, in GABAergic Transmission and Anxiety, ed. G. Biggio et al, Raven Press, New York, 1986, pp. 161-176
C. Martini et al, in GABAergic Transmission and Anxiety, ed. G. Biggio et al, Raven Press, New York, 1986, pp. 1-10
G. Bartholini et al, in L.E.R.S., vol. 3, ed. G. Bartholini et al, Raven Press, New York, 1985, pp. 1-30
D. N. Stephens et al, in GABAergic Transmission and Anxiety, ed. G. Biggio et al, Raven Press, New York, 1986, pp. 91-106
R. W. Olsen et al, in GABAergic Transmission and Anxiety, ed. G. Biggio et al, Raven Press, New York, 1986, pp. 21-32
T. Lemperiere et al, in L.E.R.S., vol. 4, ed. G. Bartholini et al, Raven Press, New York, 1986, pp. 161-162
M. Toscana Aguilar et al, in L.E.R.S., vol. 4, ed. G. Bartholini et al, Raven Press, New York, 1986, pp. 167-168
R. Volmat et al, in L.E.R.S., vol. 4, ed. G. Bartholini et al, Raven Press, New York, 1986, pp. 169-170
F. G. Graeff et al, in L.E.R.S., vol. 4, ed. G. Bartholini et al, Raven Press, New York, 1986, p. 101
A. Guidotti et al, in L.E.R.S., vol. 3, ed. G. Bartholini et al, Raven Press, New York, 1985, pp. 31-41
G. Bartholini, in L.E.R.S., vol. 4, ed. G. Bartholini et al, Raven Press, New York, 1986, pp. 1-7
Worms et al, J. Pharmacol. Exp. Ther., vol. 220, No. 3, pp. 660-671 (1982)