Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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AbstractAn osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme inhibitor and nonsteroidal antiinflammatory drugs, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system. | InventorsAssigneeApplicationNo. 06/912712 filed on 09/29/1986US Classes:424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/474, Coated pills or tablets424/486, Synthetic polymer428/320.2, Composite having a component wherein a constituent is liquid or is contained within preformed walls (e.g., impregnant-filled, previously void containing component, etc.)428/913, MATERIAL DESIGNED TO BE RESPONSIVE TO TEMPERATURE, LIGHT, MOISTURE, ETC.604/892.1Osmotic or diffusion pumped device or systemExaminersPrimary: Schofer, Joseph L.Assistant: Teskin, F. M. Attorney, Agent or FirmUS Patent References4008719, Osmotic system having laminar arrangement for programming delivery of active agentIssued on: 02/22/1977 Inventor: Theeuwes , et al.4014334, Laminated osmotic system for dispensing beneficial agent Issued on: 03/29/1977 Inventor: Theeuwes , et al.4063064, Apparatus for tracking moving workpiece by a laser beam Issued on: 12/13/1977 Inventor: Saunders , et al.4077407, Osmotic devices having composite walls Issued on: 03/07/1978 Inventor: Theeuwes , et al.4093708, Osmotic releasing device having a plurality of release rate patterns Issued on: 06/06/1978 Inventor: Zaffaroni, et al.4100098, Stabilized solutions of sodium dithionite Issued on: 07/11/1978 Inventor: Magan4111202, Osmotic system for the controlled and delivery of agent over time Issued on: 09/05/1978 Inventor: Theeuwes4186184, Selective administration of drug with ocular therapeutic system Issued on: 01/29/1980 Inventor: Zaffaroni4210139, Osmotic device with compartment for governing concentration of agent dispensed from device Issued on: 07/01/1980 Inventor: Higuchi4224427, Process for preparing hydrogels as spherical beads of large size Issued on: 09/23/1980 Inventor: Mueller , et al.4285987, Process for manufacturing device with dispersion zone Issued on: 08/25/1981 Inventor: Ayer , et al.4298003, System for delivering agent at zero order rate with emerging agent below saturation Issued on: 11/03/1981 Inventor: Theeuwes , et al.4320759, Dispenser with diffuser Issued on: 03/23/1982 Inventor: Theeuwes4327725, Osmotic device with hydrogel driving member Issued on: 05/04/1982 Inventor: Cortese , et al.4350271, Water absorbing fluid dispenser Issued on: 09/21/1982 Inventor: Eckenhoff4455143, Osmotic device for dispensing two different medications Issued on: 06/19/1984 Inventor: Theeuwes , et al.4608048, Dispensing device with drug delivery patterns Issued on: 08/26/1986 Inventor: Cortese , et al.4610686, Controlled delivery of haloperidol by an osmotic delivery system Issued on: 09/09/1986 Inventor: Ayer , et al.4612008, Osmotic device with dual thermodynamic activity Issued on: 09/16/1986 Inventor: Wong , et al.4643731Means for providing instant agent from agent dispensing system Issued on: 02/17/1987 Inventor: Eckenhoff International ClassA61K 9/00 (20060101) |