Patent ReferencesPolymeric diffusion matrix containing clonidine Polymeric diffusion matrix containing phenylephrine Polymeric diffusion matrix containing ester derivatives of estradiol Bioerodible diaphragm Polymeric diffusion matrix containing propranolol Trinitroglycerol sustained release vehicles and preparation therefrom Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills Patent #: 4642233 InventorsAssigneeApplicationNo. 06/842187 filed on 03/21/1986US Classes:424/486, Synthetic polymer424/485Natural gums, resin or latexExaminersPrimary: Page, Thurman K.Assistant: Horne, Leon R. Attorney, Agent or FirmInternational ClassesA61K 9/70 (20060101)A61K 47/32 (20060101) Foreign Application Priority Data1985-03-25 JPAbstractTransdermal dosage compositions are prepared from hydrated poly(vinyl alcohol) gels and pharmacologically active substances without any chemicals such as crosslinking agents and catalysts. Heating process is not involved in the gel preparation. High water contents of the gels enable the stratum corneum to be swollen, resulting in high permeation of drugs through the skin. | |