Patent 4780316 Issued on October 25, 1988. Estimated Expiration Date: October 1, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
424/456, Gelatin424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/452, With claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.)424/455Containing emulsions, dispersions, or solutions
A pharmaceutical dosage unit form comprises one or more pharmaceutically active materials dissolved or suspended in a liquid polyethylene glycol and encapsulated in a soft gelatin capsule shell, in which the capsule shell comprises gelatin, a plasticizer therefor, and an embrittlement inhibiting composition comprising a mixture of sorbitol and at least one sorbitan. Preferably the polyethylene glycol also contains glycerin, sorbitol or propylene glycol.
Other References
Johnson et al., "The Comparability of Dosage Regimens of Lanoxin Tablets and Lanoxicaps," British Journal of Clinical Pharmacology 4, pp. 209-211 (1977)
Ebert, "Soft Elastic Gelatin Capsules: A Unique Dosage Form," reprints from Pharmaceutical Technology (Oct. 1977)