Polypeptide cartilage-inducing factors found in bone
Patent 4774322 Issued on September 27, 1988. Estimated Expiration Date: 
December 10, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 10, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesBone morphogenetic protein process Partially purified osteogenic factor and process for preparing same from demineralized bone Inductive collagen based bone repair preparations Patent #: 4563350 InventorsAssigneeApplicationNo. 07/129864 filed on 12/10/1987US Classes:530/353, Scleroproteins, e.g., fibroin, elastin, silk, etc.514/21, Produced by or extracted from animal tissue530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/840, Bones; tendons; teeth; cartilage623/924, MATERIAL CHARACTERISTIC930/120Growth hormone, growth factor other than T-cell or B-cell growth factor, and growth hormone releasing factor; related peptidesExaminersPrimary: Phillips, Delbert R.Assistant: Nutter, Nathan M. Attorney, Agent or FirmInternational ClassesA61L 27/00 (20060101)A61L 27/22 (20060101) C07K 14/435 (20060101) C07K 14/495 (20060101) A61K 38/00 (20060101) Foreign Application Priority Data1985-07-08 EPAbstractTwo proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-ଲ assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-ଲ whereas the other has an N-terminal sequence that is different from that of TGF-ଲ derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.Other References
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