Immunochemical methods for the detection of antibody against HTLV-III
Patent 4774175 Issued on September 27, 1988. Estimated Expiration Date: 
September 27, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 27, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSerological detection of antibodies to HTLV-III in sera of patients with AIDS and pre-AIDS conditions Synthetic antigen for the detection of AIDS-related disease Patent #: 4629783 InventorsAssigneeApplicationNo. 06/707066 filed on 03/01/1985US Classes:435/5, Involving virus or bacteriophage435/180, Carrier is synthetic polymer435/805, TEST PAPERS435/974, AIDS RELATED TEST436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/528, Carrier is organic436/531, Carrier is synthetic resin436/811, TEST FOR NAMED DISEASE, BODY CONDITION OR ORGAN FUNCTION530/324, 25 or more amino acid residues in defined sequence930/10, PEPTIDE OR PROTEIN SEQUENCE930/221Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus relatedExaminersPrimary: Nucker, Christine M.Attorney, Agent or FirmInternational ClassesC12Q 1/70 (20060101)C07K 14/005 (20060101) C07K 14/16 (20060101) A61K 38/00 (20060101) AbstractGene segments of human T cell lymphotropic virus type III (HTLV-III) were expressed in E. coli as peptides that are reactive with sera from patients with acquired immune deficiency syndrome (AIDS). Among recombinant peptides one designated HTLV-III polypeptide 121, contained 85 amino acid residues encoded by a gene segment in the env-lor region of the HTLV-III genome. The polypeptide is strongly reactive with AIDS patient sera. The peptide produced and purified as a fusion protein on a large scale. Solid phase immunoassays employing this recombinant peptide as an immunoabsorbent can reliably and reproducibly detect antibodies in sera of patients with HTLV-III infection. In two representative serum panels, the assay detected the presence of antibodies in 120 of 121 sera from patients with AIDS or AIDS-related complex (ARC), and only in 1 of 92 normal controls. Based upon HTLV-III polypeptide 121 as immunoreactive agent, sensitive and specific immunoassays for HTLV-III infection have been developed.Other References
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