Process for the preparation of codeine from morphine
Patent 4764615 Issued on August 16, 1988. Estimated Expiration Date: 
December 10, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 10, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsApplicationNo. 06/940517 filed on 12/10/1986US Classes:546/44One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)ExaminersPrimary: Daus, Donald G.Assistant: Rivers, Diana G. Attorney, Agent or FirmInternational ClassesC07D 489/02 (20060101)C07D 489/00 (20060101) AbstractCodeine is prepared by reacting morphine with trimethyl phenyl ammonium chloride in the presence of an alkali metal carbonate and a hydrocarbon solvent at a temperature of from 40° to 120° C. Codeine is recovered from the reaction mixture. Codeine is useful as an analgesic and antitussive drug.Other References
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