Novel cyclosporins
Patent 4764503 Issued on August 16, 1988. Estimated Expiration Date: 
May 13, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 13, 2007. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesDihydrocyclosporin C Organic compounds Organic compounds Patent #: 4220641 InventorAssigneeApplicationNo. 07/049746 filed on 05/13/1987US Classes:514/11, Monocyclic530/317, Cyclic peptides930/190, Antibiotic930/20, Containing modified or unusual amino acid (See note 1 and note 2)930/21, Containing D-amino acid930/270Cyclic peptide or cyclic protein (See note 8)ExaminersPrimary: Phillips, Delbert R.Attorney, Agent or FirmInternational ClassesC07K 7/00 (20060101)C07K 7/64 (20060101) A61K 38/00 (20060101) AbstractCyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy--amino acid residue, typically of formula ##STR1## wherein X=--MeBmt-- or --dihydro--MeBmt--, Y=--u--, --Ala--, --Thr--, --Val-- or --Nva--, Z=--Val-- or --Nva-- and Q=R1 --CO--O--CH(R2)--CH(CO--)--NH-- wherein R1 =H, C1-4 alkyl or phenyl and R2 =H or CH3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity. |
| ||||||||||||||
