Pharmaceutical preparation containing ibuprofen and a process for its preparation
Patent 4762702 Issued on August 9, 1988. Estimated Expiration Date: 
November 4, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 4, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3676549 3764668 3772430 3773922 3875073 3882228 3887700 Method of delivering drug with aid of effervescent activity generated in environment of use Therapeutic compositions with enhanced bioavailability Cleansing tablets for tooth prostheses InventorsApplicationNo. 06/794636 filed on 11/04/1985US Classes:424/44, Gas produced in situ by chemical reaction424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/500, Contains natural gums and resins424/501, Contains solid synthetic resin514/570Carboxy or salt thereof only attached indirectly to the benzene ringExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassesA61K 9/16 (20060101)A61K 9/46 (20060101) A61K 31/19 (20060101) A61K 31/185 (20060101) Foreign Application Priority Data1984-11-05 DEAbstractA pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.Other References
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