U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Pharmaceutical preparation containing ibuprofen and a process for its preparation

Patent 4762702 Issued on August 9, 1988. Estimated Expiration Date: Icon_subject November 4, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3676549

3764668

3772430

3773922

3875073

3882228

3887700

Method of delivering drug with aid of effervescent activity generated in environment of use
Patent #: 4344929
Issued on: 08/17/1982
Inventor: Bonsen ,   et al.

Therapeutic compositions with enhanced bioavailability
Patent #: 4344934
Issued on: 08/17/1982
Inventor: Martin ,   et al.

Cleansing tablets for tooth prostheses
Patent #: 4417993
Issued on: 11/29/1983
Inventor: Gergely

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Inventors

Application

No. 06/794636 filed on 11/04/1985

US Classes:

424/44, Gas produced in situ by chemical reaction424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/500, Contains natural gums and resins424/501, Contains solid synthetic resin514/570Carboxy or salt thereof only attached indirectly to the benzene ring

Examiners

Primary: Rose, Shep K.

Attorney, Agent or Firm

International Classes

A61K 9/16 (20060101)
A61K 9/46 (20060101)
A61K 31/19 (20060101)
A61K 31/185 (20060101)

Foreign Application Priority Data

1984-11-05 DE

Abstract

A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.

Other References

  • Kowa II, CA., 95 #156580m (1981) of JPN 81 46837, 28 Apr. 1981
  • Chow, CA., 105 #48887h (1986) of Int. J. Pharm. 28(2-3), 95-101 (1986)
  • Hayashi, CA., 94 #90331b (1981) of JPN 80 01,244, 12 Jan. 1980
  • Corrigan, CA., 103 #76147u (1985) of Drug Dev. Ind. Pharm. 11(2-3): 677-695 (1985)
  • Kurozumi, CA., 84 #111578y (1976) of Chem. Pharm. Bull., 23(12): 30628 (1978)
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