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US Patent 4762702 - Pharmaceutical preparation containing ibuprofen and a process for its preparation
US Patent Issued on August 9, 1988
Estimated Patent Expiration Date:
November 4, 2005Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
November 4, 2005Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractA pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.Other References
| InventorsApplicationNo. 06/794636 filed on 11/04/1985US Classes:424/44, Gas produced in situ by chemical reaction424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/500, Contains natural gums and resins424/501, Contains solid synthetic resin514/570Carboxy or salt thereof only attached indirectly to the benzene ringField of Search424/44, Gas produced in situ by chemical reaction424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/500Contains natural gums and resinsExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmUS Patent References3676549, 3764668, 3772430, 3773922, 3875073, 3882228, 3887700, 4344929, Method of delivering drug with aid of effervescent activity generated in environment of useIssued on: 08/17/1982 Inventor: Bonsen , et al.4344934, Therapeutic compositions with enhanced bioavailability Issued on: 08/17/1982 Inventor: Martin , et al.4417993, Cleansing tablets for tooth prostheses Issued on: 11/29/1983 Inventor: Gergely4540602, Process for the preparation of activated pharmaceutical compositions Issued on: 09/10/1985 Inventor: Motoyama , et al.4593020, Therapeutic methods for the treatment of hangover Issued on: 06/03/1986 Inventor: Guinot4613497, Dry, water-foamable pharmaceutical compositions Issued on: 09/23/1986 Inventor: Chavkin4614648, Process for manufacturing effervescent granules and tablets Issued on: 09/30/1986 Inventor: Bru4678661Effervescent composition and method of making same Issued on: 07/07/1987 Inventor: Gergely , et al. International ClassesA61K 9/16 (20060101)A61K 9/46 (20060101) A61K 31/19 (20060101) A61K 31/185 (20060101) Foreign Application Priority Data1984-11-05 DE |
