U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Multiphase liposomal drug delivery system

Patent 4761288 Issued on August 2, 1988. Estimated Expiration Date: Icon_subject September 10, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3645911

3804776

Method of preparing a controlled release liquid pharmaceutical composition
Patent #: 4016100
Issued on: 04/05/1977
Inventor: Suzuki ,   et al.

Topical steroid formulation in form of lotion or cream
Patent #: 4048310
Issued on: 09/13/1977
Inventor: Chen, et al.

Process for the preparation of liposomes
Patent #: 4089801
Issued on: 05/16/1978
Inventor: Schneider

Method of encapsulating biologically active materials in lipid vesicles
Patent #: 4235871
Issued on: 11/25/1980
Inventor: Papahadjopoulos ,   et al.

Immunoassay products and methods
Patent #: 4342826
Issued on: 08/03/1982
Inventor: Cole

Process and device for producing bilayer vesicles
Patent #: 4438052
Issued on: 03/20/1984
Inventor: Weder ,   et al.

Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
Patent #: 4485054
Issued on: 11/27/1984
Inventor: Mezei ,   et al.

Method of preparing giant size liposomes Patent #: 4532089
Issued on: 07/30/1985
Inventor: MacDonald

Inventor

Assignee

Application

No. 06/774266 filed on 09/10/1985

US Classes:

424/450, Liposomes264/4.6, Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.)428/402.2, Microcapsule with fluid core (includes liposome)436/829, LIPOSOMES (E.G., ENCAPSULATION, ETC.)514/272, Nitrogen bonded directly to the 1,3-diazine at 2-position514/78, Lecithins514/880, HAIR TREATMENT (THERAPEUTIC-SCALP)514/887, Topical Treatment514/944GEL

Examiners

Primary: Lovering, Richard D.

Attorney, Agent or Firm

International Classes

A61K 9/127 (20060101)
A61K 31/415 (20060101)
A61K 31/505 (20060101)

Abstract

The present invention provides a novel multiphase drug delivery system which comprises:(a) lipid vesicles with a biologically active compound captured therein;(b) a saturated solution of the biologically active compound; and(c) the biologically active compound in solid form.Optionally this composition is dispersed in a hydrocolloid gel.

Other References

  • European Search Report (Appln.) No. 85306641.3, 4-1987
  • Cecil--"Textbook of Medicine", vol. 1, (1982), pp. 1276-1278
  • Chemical Abstracts, vol. 97, No. 22, (1982), Abstract No. 188156k
  • Theoharides, "Liposomes as Carriers of Biologically Active Molecules", Folia Bioch. et Biol. Graeca, Special Issue, vol. XIV, pp. 11-21, (1978)
  • Mezei, "Liposomes--A Selective Drug Delivery System for the Topical Route of Administration: Gel Dosage Form", J. Pharm. Pharmacol., 1982, 34:473-474
  • Mezei et al., Life Sciences, vol. 26, pp. 1473-1477, (1980)
  • Bangham, et al., Methods in Membrane Biology, 6, (London, 1974)
  • Bangham, et al., Chem. Phys. Lipids 1:266, (1967)
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