U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

17ଲ-N-monosubstituted carbamoyl-4-aza-5଱-androst-1-en-3-ones which are active as testosterone 5଱-reductase inhibitors

Patent 4760071 Issued on July 26, 1988. Estimated Expiration Date: Icon_subject November 21, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

2227876

3239417

3264301

3285918

Preparation of 4-aza-17-substituted-5଱-androstan-3-ones useful as 5଱-reductase inhibitors
Patent #: 4220775
Issued on: 09/02/1980
Inventor: Rasmusson ,   et al.

4-Aza-17ଲ-substituted-5଱-androstan-3-one-reductase inhibitors Patent #: 4377584
Issued on: 03/22/1983
Inventor: Rasmusson ,   et al.

Inventors

Assignee

Application

No. 06/800623 filed on 11/21/1985

US Classes:

514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos514/859, Acne546/77The six-membered hetero ring shares ring members with one other cyclo only

Examiners

Primary: Daus, Donald G.
Assistant: Rivers, Diana G.

Attorney, Agent or Firm

International Classes

C07J 73/00 (20060101)
C07C 62/00 (20060101)
C07C 62/38 (20060101)

Abstract

This invention is for the compound 17ଲ-(N-t-butylcarbamoyl)-4-aza-5଱-androst-1-en-3-one, pharmaceutical compositions containing the compound, methods of inhibiting testosterone 5଱-reductase with the compound and methods of treating hyperandrogenic conditions with the compound, particularly benign prostatic hypertrophy.

Other References

  • Brooks, et al., The Prostate, vol. 9, pp. 65-75, (1986)
  • Neri et al., A Biological Profile of a Nonsteroidal Antiandrogen, Endo, 1972, vol. 91, No. 2, pp. 427-437
  • Nayfe et al., Metabolism of Progesterone by Rat Testicular Homogenates, 9/69, Steroids, pp. 269-283
  • Doorenbos & Solomons; Synthesis & Antimicrobial Properties of 17ଲ-Isopentyloxy-4-aza-5଱-androstane & 4-Methyl Derivative; J. Pharm. Sci. 62, 4, pp. 638-640, (1973)
  • Doorenbos & Brown; 4,17଱-Dimethyl-4-aza-5଱-androstan-17ଲ-ol Acetate & Related Azasteroids; J. Pharm. Sci. 60,4, pp. 1234-1235, (1971)
  • Doorenbos & Kim., Synthesis & Evaluation of Antimicrobial Propertes of Amidinoazaandrostane & Quanidinoazaandrostanes; J. Pharm. Sci., 63,4, pp. 620-622, (1974)
  • Kedderis, G. L. et al., "Studies with Nitrogen-Containing Steroids and Freshly Isolated Rat Hepatocytes: Role of Cytochrome P-450 in Detoxication," J. Tox. Appl. Pharm., (in press)
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?