Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists
Patent 4760069 Issued on July 26, 1988. Estimated Expiration Date: 
September 23, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 23, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3135758 3153042 3320262 InventorsAssigneeApplicationNo. 06/778800 filed on 09/23/1985US Classes:514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)546/45Nitrogen or divalent chalcogen double bonded directly to carbocyclic ring of the pentacyclo ring system (e.g., morphinones, etc.)ExaminersPrimary: Rizzo, Nicholas S.Assistant: Rivers, Diana G. Attorney, Agent or FirmInternational ClassesC07D 489/00 (20060101)C07D 489/08 (20060101) AbstractA potent, selective opioid receptor agonist or antagonist exhibiting properties useful for a long-acting analgesic or opiate abuse treatment agent or appetite suppressant having the general formula: ##STR1## wherein R is methyl, cyclopropylmethyl or allyl, and R1 is an unsubstituted or substituted aryl, aralkyl, heteroaryl, heteroaralkyl or a cycloalkyl group with or without a heteroatom like S,O,N; and the pharmaceutically acceptable salts thereof.Other References
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