U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Non-invasive blood flow measurements utilizing cardiac cycle synchronization

Patent 4759374 Issued on July 26, 1988. Estimated Expiration Date: Icon_subject July 26, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Method of and apparatus for measurement of blood flow using coherent light
Patent #: 4109647
Issued on: 08/29/1978
Inventor: Stern ,   et al.

Duplex ultrasonic imaging system with repetitive excitation of common transducer in doppler modality
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Issued on: 03/24/1981
Inventor: Papadofrangakis ,   et al.

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Inventor: Papadofrangakis ,   et al.

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Patent #: 4324258
Issued on: 04/13/1982
Inventor: Huebscher ,   et al.

Noninvasive measurement of blood flow rate utilizing ultrasound
Patent #: 4327739
Issued on: 05/04/1982
Inventor: Chmiel ,   et al.

Method and system for non-invasive ultrasound Doppler cardiac output measurement
Patent #: 4509526
Issued on: 04/09/1985
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Inventors

Assignee

Application

No. 06/730456 filed on 05/06/1985

US Classes:

600/455, Pulse Doppler73/861.25Reflection or scattering of acoustic waves

Examiners

Primary: Jaworski, Francis J.

Attorney, Agent or Firm

International Class

A61B 8/06 (20060101)

Abstract

A system for non-invasively determining the amount of blood flow by performing an autoregressive analysis of Doppler shifted acoustical signals resulting from reflected ultrasonic signals from blood cell movement within internal blood vessels. Each cardiac cycle is determined by an analysis of the patient's electrocardiogram signals,and the resulting cardiac cycles are divided into a predefined number of time segments or channels each containing Doppler shifted signals. The autoregressive analysis is then performed over each individual channel to determine reflection coefficients that model the blood flow and a residual energy level that indicates the energy not accounted for by that modeling. The reflection coefficients results result from a linear predictive code analysis, and the term "reflection coefficients" is not used in the customary manner as defined for ultrasonic flow analysis of blood as defining a level of reflected acoustic energy. A power spectrum analysis is then performed utilizing the reflection coefficients and residual energy level for each channel. Then, the power spectra of individual channels of all of the cycles are averaged together producing a group of averaged channels representing the average blood flow through the patient's internal vessel over all of the cardiac cycles. These averaged power spectra for each combined channel are then normalized and displayed on a channel-by-channel basis utilizing different colors to represent the different power levels. The utilization of different colors greatly enhances the ability of medical personnel to make diagnostic decisions regarding the amount of blood flow.

Other References

  • Brian, P. et al, "Off Line Computation of LV BF Field Derived from Doppler UTS Velocimetry", Conf: Computers in Cardiology Sep. 12-, 1978, Stanford, Cal., IEEE CH1391-2/78/0000-0175, pp. 175-178
  • "Computer Based Pattern Recognition of Carotid Artery Doppler Signals for Desease Classification: Prospective Validation", Y. E. Langlois, et al., Ultrasound in Med. & Biol., 1984, vol. 10, No. 5, pp. 581-595
  • "Analysis and Automatic Classification of Breath Sounds", A. Cohen, et al., IEEE Transactions on Biomedical Engineering, Sep., 1984, vol. BME-31, No. 9, pp. 585-590
  • "Flow Velocity Patterns in the Carotid Bifurcations of Young, Presumed Normal Subjects", D. J. Phillips, et al., Ultrasound in Med. & Biol., 1983, vol. 9, No. 1, pp. 39-49
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