U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Inducing analgesia by implantation of cells releasing neuroactive substances

Patent 4753635 Issued on June 28, 1988. Estimated Expiration Date: Icon_subject May 23, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Enkephalin-like compounds in bovine adrenal medulla
Patent #: 4264492
Issued on: 04/28/1981
Inventor: Stein

Encapsulation of live animal cells
Patent #: 4353888
Issued on: 10/12/1982
Inventor: Sefton

Enzyme-resistant opiate pentapeptides
Patent #: 4371463
Issued on: 02/01/1983
Inventor: Pert ,   et al.

Enkephalin-like compounds in bovine adrenal medulla Patent #: 4388236
Issued on: 06/14/1983
Inventor: Stein

Inventors

Application

No. 06/866479 filed on 05/23/1986

US Classes:

604/522, Introduction of biologically derived compounds (i.e., growth hormones or blood products) including cells514/818, ANESTHETIC, LOCAL604/512, For anesthetizing patient604/891.1Implanted dynamic device or system

Examiners

Primary: Rosenbaum, C. Fred
Assistant: Rose, Sharon

Attorney, Agent or Firm

International Classes

A61K 35/12 (20060101)
A61F 2/02 (20060101)

Abstract

A method of inducing analgesia or reducing pain is described. The method involves implanting in the central nervous system of a host susceptible to pain, living material capable of releasing effective amount of analgesic substance when interacted with a stimulus which induces said material to release analgesic amount of said substance. The procedure described herein reduces sensitivity to intractable pain.

Other References

  • Freed et al., Transplanted Adrenal Chromaffin Cells in Rat Brain Induce Lesion Induced Rotational Behavior, Nature 292: 351-352 (1981)
  • Backlund et al. Transplantation of Adrenal Medullary T. Tissup to Striatum in Parkinsonism, Neural Grafting in the Mammalion Central Nervous System, pp. 551-556 (1985)
  • Snyder, Solomon H., Opiate Receptors and Internal Opiates, Scientific American, Mar. 1977, pp. 44-56
  • Mizobe, Fumio and Livett, Bruce G., Nicotine Stimulates Secretion of Both Catecholamines and Acetylcholinesterase from Cultured Adrenal Chromaffin Cells, Journal of Neuroscience, vol. 3, No. 4, pp. 871-876, Apr. 1983
  • Olson et al., Transplantation in Parkinsons Disease, Arnals of the New York Academy of Sciences, vol. 457, pp. 105-126, 1985
  • J. Neurochem 36(3) 1981 886-892, Advances in Biochemical Psychopharmocology, vol. 22, pp. 571-580
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