Targeting conjugates of albumin and therapeutic agents
Patent 4749570 Issued on June 7, 1988. Estimated Expiration Date: 
December 31, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 31, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesImmunological materials Conjugates of prostaglandins, analogs, formulations and their use Process for preparing an antipregnancy vaccine Propanolol antigen conjugates and antibodies Patent #: 4241177 InventorAssigneeApplicationNo. 06/815752 filed on 12/31/1985US Classes:435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate424/155.1, Cancer cell424/172.1, Binds eukaryotic cell or component thereof or substance produced by said eukaryotic cell (e.g., honey, etc.)424/178.1, CONJUGATE OR COMPLEX OF MONOCLONAL OR POLYCLONAL ANTIBODY, IMMUNOGLOBULIN, OR FRAGMENT THEREOF WITH NONIMMUNOGLOBULIN MATERIAL424/809, INVOLVING IMMUNOGLOBULIN OR ANTIBODY FRAGMENT (E.G., F(AB`)2, FAB`, FV, FC, HEAVY CHAIN, LIGHT CHAIN, ETC.)424/94.3, Stabilized enzymes or enzymes complexed with nonenzyme (e.g., liposomes, etc.)530/388.8, Binds cancer cell or component or product thereof (e.g., cell-surface antigen, etc.)530/389.1, Polyclonal antibody or immunogloblin of identified binding specificity530/391.7Conjugated to a cytotoxic agent, drug, or other biologically-active substanceExaminersPrimary: Hazel, BlondelAttorney, Agent or FirmInternational ClassA61K 38/43 (20060101)AbstractThe invention provides a conjugate comprising an enzyme having its antigenic sites or antigenicity masked by albumin and having a targeting agent attached, and a method for its preparation. The albumin is included in an amount sufficient to mask antigenicity of the enzyme. The targeting agent used has binding specificity for receptor sites on cells towards which it is desirable to direct the enzyme. Insulin, immunoglobulin G, antibody against human pancreatic tumor cell, and antibody against hyaluronic acid are exemplified as targeting agents.Other References
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