Polysubstituted aryl acridinium esters

Patent 4745181 Issued on May 17, 1988. Estimated Expiration Date:

October 6, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Chemiluminescent-labeled haptens and antigens
Patent #: 4363759
Issued on: 12/14/1982
Inventor: Boguslaski , et al.

Novel substrates for use in measuring the concentration of kallikrein in urine
Patent #: 4650753
Issued on: 03/17/1987
Inventor: Nagasawa , et al.

Bioluminescent assay reagent and method Patent #: 4665022
Issued on: 05/12/1987
Inventor: Schaeffer , et al.

Inventors

Assignee

Ciba Corning Diagnostics Corp.

Application

No. 06/915527 filed on 10/06/1986

US Classes:

530/391.5, Conjugated via a specifically-identified linking group, chelating group, coordination complex, coupling agent, or conjugation agent530/802, CHROMOGENIC OR LUMINESCENT PEPTIDES536/18.7, Nitrogen containing536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/25.3, Synthesis of polynucleotides or oligonucleotides546/102, Acridines (including hydrogenated)546/104, Nitrogen, other than as nitro or nitroso, attached directly or indirectly to the acridine ring system by nonionic bonding546/107Plural nitrogens, other than as nitro or nitroso, attached directly to the carbocyclic rings of the acridine ring system (e.g., 3,6-diaminoacridines, etc.)

Examiners

Primary: Phillips, Delbert R.

Attorney, Agent or Firm

Reitenbach; Daniel

International Classes

C07D 219/00 (20060101)
C07D 219/04 (20060101)

Abstract

The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.