Sensor having piezoelectric crystal for microgravimetric immunoassays
April 5, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3164004 3863495 Apparatus for measuring a sorbate dispersed in a fluid stream Protein immobilizer Method for the assay of classes of antigen-specific antibodies Immunoassay for antigens Method of detecting adherent cells Methods of detection with surface acoustic wave and apparati therefor Sandwich immunoassay using piezoelectric oscillator Method and apparatus for sensing fluids using surface acoustic waves Patent #: 4361026 InventorAssigneeApplicationNo. 06/675524 filed on 11/28/1984US Classes:436/527, Glass or silica324/71.1, DETERMINING NONELECTRIC PROPERTIES BY MEASURING ELECTRIC PROPERTIES367/157, Piezoelectric436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/806ELECTRICAL PROPERTY OR MAGNETIC PROPERTYExaminersPrimary: Marantz, SidneyAttorney, Agent or FirmInternational ClassesG01N 29/02 (20060101)G01N 33/543 (20060101) AbstractA sensor and method for performing immunoassays using surface acoustic waves on a piezoelectric crystal is provided. A specific antigen or antibody is bonded to the surface of the piezoelectric crystal and its resonant frequency in a blank solution is determined. The sensor is then exposed to a test solution containing an antigen or antibody corresponding to the substance bonded to the surface of the crystal. As the antigen and antibody react, the resonant frequency of the crystal is altered. This change can be correlated to determine the amount of antigen or antibody in the test solution. A nonreactive reference sensor can also be used to compensate for any nonselective adsorption.Other References
|
| ||||||||||||||
