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Steroidic 5଱-reductase inhibitors

Patent 4732897 Issued on March 22, 1988. Estimated Expiration Date: Icon_subject February 3, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Preparation of 4-aza-17-substituted-5଱-androstan-3-ones useful as 5଱-reductase inhibitors
Patent #: 4220775
Issued on: 09/02/1980
Inventor: Rasmusson ,   et al.

4-Aza-17ଲ-substituted-5଱-androstan-3-one-reductase inhibitors
Patent #: 4377584
Issued on: 03/22/1983
Inventor: Rasmusson ,   et al.

Bile acids Patent #: 4388241
Issued on: 06/14/1983
Inventor: Monks

Inventors

Application

No. 06/825348 filed on 02/03/1986

US Classes:

514/228.2, Polycyclo ring system having the additional hetero ring as one of the cyclos514/232.8, Polycyclo ring system having the additional hetero ring as one of the cyclos514/253.02, Polycyclo ring system having the additional six-membered nitrogen hetero ring as one of the cyclos514/284, Tetracyclo ring system having the six-membered hetero ring as one of the cyclos544/125, The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system544/361, The additional six-membered hetero ring is one of the cyclos in a polycyclo ring system544/60, Additional hetero ring containing546/77, The six-membered hetero ring shares ring members with one other cyclo only546/78, Plural chalcogens bonded directly to carbocyclic rings of the tetracyclo ring system (e.g., pyridoanthraquinones, etc.)552/552, Exactly one oxygen bonded directly to the cyclopentanohydrophenanthrene ring system (e.g., 3-hydroxycholanic acids, lithocholic acids, etc.)560/5, Hydrophenanthrene in acid moiety562/403Hydrophenanthrene nucleus

Examiners

Primary: Daus, Donald G.
Assistant: Rivers, Diana G.

Attorney, Agent or Firm

International Classes

C07J 73/00 (20060101)
C07J 41/00 (20060101)

Foreign Application Priority Data

1985-03-07 GB

Abstract

The present invention relates to new 4-aza-17ଲ-substituted 5଱-androstan-3-ones, to a process for their preparation, to pharmacological compostions containing them, and to the use of said compounds as inhibitors of androgen action by means of testosterone 5-reductase inhibition.

Other References

  • Doorenbos et al., Chemical Abstracts, vol. 63; 10017c-e (1965)
  • Varricchio, Chemical Abstracts, vol. 66:44027f (1967)
  • Shoppee et al., J. Chem. Soc. (1962), pp. 2275-2285
  • Djerassi, "Steroid Reactions, an Outline for Organic Chemists", Holden-Day, Inc., San Francisco (1963), pp. 513-518
  • Rasmusson G. H. et al., "Azasteroids as Inhibitors of Rat Prostatic 5-Reductase" J. Med. Chem. 1984, 27, 1690-1701
  • Farmdoc Abstract 794038/44, Merck & Co., Inc. EP 4949, 1979
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