L--amino acids as transdermal penetration enhancers
Patent 4732892 Issued on March 22, 1988. Estimated Expiration Date: 
July 12, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
July 12, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3527864 3787571 Vehicle composition containing 1-substituted azacycloheptan-2-ones Therapeutic compounds for the treatment of uro-genital disorders Transdermal carrier materials Highly concentrated preparations of dopa compounds Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone Patent #: 4537776 InventorsAssigneeApplicationNo. 06/754805 filed on 07/12/1985US Classes:514/178, Oxygen single bonded to a ring carbon of the cyclopentanohydrophenanthrene ring system514/171, With additional active ingredient514/179, Modified C-ring (except methyl in 13-position) (e.g., double bond containing, substituted, etc.)514/561, Nitrogen other than as nitro or nitroso nonionically bonded514/843, Female (mammal)514/947Topical applicationExaminersPrimary: Schenkman, LeonardAttorney, Agent or FirmInternational ClassesA61K 47/18 (20060101)A61K 47/16 (20060101) A61K 31/185 (20060101) A61K 31/195 (20060101) A61K 31/40 (20060101) A61K 31/403 (20060101) A61K 31/405 (20060101) A61K 31/565 (20060101) AbstractThe disclosed invention provides methods and compositions ulilizing L--amino acids for enhancing the rate of penetration through the skin of both topical medicaments and of drugs employed for systemic administration. Fifteen L--amino acids were tested and found to enhance the rate of penetration of levonorgestrel through hairless mouse skin. These were Tryptophan, Glutamic Acid, Glycine, Proline, Alanine, Serine, Arginine, Aspartic Acid, Leucine, Isoleucine, Cysteine, Valine, -Aminobutyric Acid, Norvaline and Norleucine. The effect of pH on the rate of penetration of the various amino acids was also examined and found to be unpredictable overall. | |
