Gut-selective opiates
Patent 4730048 Issued on March 8, 1988. Estimated Expiration Date: 
December 12, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 12, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3320262 Selective opioid receptor alkylating agents Non-addictive narcotic antitussive preparation Opiate agonists and antagonists Patent #: 4608376 InventorAssigneeApplicationNo. 06/809051 filed on 12/12/1985US Classes:546/45, Nitrogen or divalent chalcogen double bonded directly to carbocyclic ring of the pentacyclo ring system (e.g., morphinones, etc.)546/44, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)546/46, A single chalcogen is bonded directly to ring carbon of the pentacyclo ring system (e.g., desoxy morphine, etc.)562/560, Ureido, hydrazino, or nitrogen double bonded directly to carbon562/565PolycarboxylicExaminersPrimary: Daus, Donald G.Assistant: Rivers, Diana G. Attorney, Agent or FirmInternational ClassesC07D 489/06 (20060101)C07D 489/00 (20060101) AbstractGut-selective agonist or antagonist opiates of the formula: ##STR1## wherein R is (C1 -C5)alkyl, C3 -C6 (cycloalkyl)alkyl, aryl, aralkyl or trans-(C2 -C5)alkenyl; Z is H or OH, R' is (C=O)-A(B)(C) wherein A is selected from the group consisting of (C1 -C5)alkyl, (C2 -C5)alkenyl and (C2 -C6)alkoxy (alkyl); B is selected from the group consisting of H, amino and a (C1 -C5)alkyl group optionally substituted with CO2 H, OH or phenyl and C is CO2 H, SO3 H, amino or guanidino; and R" is selected from the group consisting of NH-A(B)(C) or is guanidino; and the pharmaceutically-acceptable salts thereof.Other References
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