Formulations providing three distinct releases
Patent 4728512 Issued on March 1, 1988. Estimated Expiration Date: 
March 4, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 4, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2809918 2921883 3119742 3175521 3835221 3859431 Sustained release pharmaceutical composition Sustained release indomethacin Sustained release pharmaceutical compositions Sustained release pharmaceutical compositions InventorsAssigneeApplicationNo. 06/836033 filed on 03/04/1986US Classes:424/458, Containing discrete coated particles pellets, granules, or beads424/453, Telescoping two piece424/457, Sustained or differential release424/459, Organic coatings424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462Containing solid synthetic polymersExaminersPrimary: Rose, Shep K.Attorney, Agent or FirmInternational ClassA61K 9/50 (20060101)AbstractA therapeutic preparation consisting of three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance a second group of spheroids is coated with a pH sensitive coat to provide a second dose and a third group of spheroids is coated with a pH independent coat to provide a third dose. A powder blend of active medicinal substance may be substituted for the first group of uncoated spheroids.The therapeutic preparation may be utilized as a mixture of groups of spheroids in a capsule.Other References
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