Pharmaceutical preparations containing cyclodextrin derivatives
Patent 4727064 Issued on February 23, 1988. Estimated Expiration Date: 
May 29, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 29, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2827452 3420788 3453257 3453259 3459731 Hormonal plant growth regulator Water-soluble steroid compounds Cyclodextrin inclusion complex of piperonyl butoxide Inclusion complex of ଲ-cyclodextrin and digoxin Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives Patent #: 4596795 InventorAssigneeApplicationNo. 06/738749 filed on 05/29/1985US Classes:514/58, Dextrin or derivative106/205.01, Carbohydrate gum, dextrin or derivative (e.g., arabic, tragacanth, guar, karaya, agar agar, algin, irish moss, etc.)106/205.6, With organic compound containing sulfur or nitrogen514/965, Discrete particles in supporting matrix514/971, Crystallization point depressant or cold stabilizer containing536/103Dextrin or derivativeExaminersPrimary: Griffin, Ronald W.Attorney, Agent or FirmInternational ClassesA61K 47/48 (20060101)A61K 31/57 (20060101) A61K 31/565 (20060101) C08B 37/00 (20060101) C08B 37/16 (20060101) AbstractThe invention comprises pharmaceutical preparations consisting generally of a drug with a substantially low water solubility and an amorphous, water-soluble cyclodextrin-based mixtures. In these preparations a stable amorphous state can be achieved. This improves the dissolution properties of the drug and hence its absorption by the body. The required cyclodextrin-based mixtures were prepared from -, ଲ-, or γ-cyclodextrin which were rendered amorphous through non-selective alkylation. The alkylation agents suitable for that purposes are exemplified by propylene oxide, glycidol, iodoacetamide, chloroacetate, or 2-diethylaminoethylchloride; their reactions with cyclodextrins were performed in a manner to yield mixtures containing many components, a circumstance which effectively prevents crystallization processes within the above pharmaceutical preparation.Other References
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