Method of enhancing the host defense

Patent 4725585 Issued on February 16, 1988. Estimated Expiration Date:

September 20, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

2850428

Ultrapure hyaluronic acid and the use thereof Patent #: 4141973
Issued on: 02/27/1979
Inventor: Balazs

Inventors

Assignee

Pharmacia AB

Application

No. 06/778560 filed on 09/20/1985

US Classes:

514/54, Polysaccharide536/55.1Polysaccharides

Examiners

Primary: Griffin, Ronald W.

Attorney, Agent or Firm

Stiefel, Gross, Kurland & Pavane

International Class

A61K 31/70 (20060101)

Abstract

The invention relates to a method of enhancing or regulating the host defense of a mammal, said method comprising administering to a mammal a therapeutically effective amount of hyaluronic acid.

Other References

Alaverdyan, "Chem. Abst.", vol. 60, p. 2203(a)
"Scand. J. Infect. Dis. Suppl.", 24:54-57, 1980, Hakansson et al
Hakansson et al., Reprint from "The Jour. of Clinical Investigation", vol. 66, No. 2, pp. 298-305, Aug. 1980
Rydell, N., et al., Effect of Intra-Articular Injection of Hyaluronic Acid on the Clinical Symptoms of Arthritis in Track Horses, published in Acta Vet. Scand., vol. 11, pp. 139-155, (1970)
Algvere, P., Intravitreal Implantation of High-Molecular Hyaluronc Acid in Surgery for Retinal Detachment, published in Acta Ophthalmologica, vol. 49, pp. 975-976, (1971)
Rydell, N., et al., Effect of Intra-Articular Injection of Hyaluronic Acid on the Clinical Symptoms of Osteoarthritis and on Granulation Tissue Formation, published in Clin. Orthop., vol. 80, pp. 25-32, (1971)
Constable, Ian J., et al., Biological Vitreous Substitutes, published in Archives of Ophthalmology, vol. 88, pp. 544-548, (1972)
Balazs, E. A., et al., Hyaluronic Acid and Replacement of Vitreous and Aqueous Humor, published in Modern Problems in Ophthalmology, vol. 10, pp. 3-21, (1972)
Peyron, Jacques G., et al., Preliminary Clinical Assessment of Na-Hyaluronate Injection into Human Arthritic Joints, published in Path. Biol., vol. 22, pp. 731-736, (1974)
Rydell, N., Decreased Granulation Tissue Reaction After Installment of Hyaluronic Acid, published in Acta Orthop. Scandinav., vol. 41, pp. 307-311, (1970)
Balazs, E. A., et al., The Effect of Hyaluronic Acid on Fibroblasts, Mononuclear Phagocytes and Lymphocites, Papers of the Symposium Held in Torku, Finland, (1972)
Kulonen, E. and Pikkarainen, J., (Ed.): Biology of the Fibroblast. I, London Academic Press, p. 237, (1973)