Pulsatile drug delivery system
Patent 4723958 Issued on February 9, 1988. Estimated Expiration Date: 
May 23, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 23, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3656483 3732865 3760804 3760806 Osmotic dispenser Osmotic device with hydrogel driving member Sustained release delivery system Delivery system controlled administration of beneficial agent to ruminants Gas diffusion-limited controlled release devices Release device InventorsAssigneeApplicationNo. 06/866415 filed on 05/23/1986US Classes:604/890.1, CONTROLLED RELEASE THERAPEUTIC DEVICE OR SYSTEM424/438, Specially adapted for ruminant animal514/30, The hetero ring has exactly 15 ring carbons604/891.1, Implanted dynamic device or system604/892.1Osmotic or diffusion pumped device or systemExaminersPrimary: Truluck, Dalton L.Assistant: Whelton, Denise Attorney, Agent or FirmInternational ClassesA61K 9/00 (20060101)A61M 31/00 (20060101) AbstractThere is provided a novel drug delivery system which provides for intermittent drug delivery with readily adjustable intervals between drug delivery pulses. This is accomplished by providing a multilayer device in which layers of active drug are readily expandable or erodable when contacted with the environment in which the drug is to be administered. The drug layer is alternated with an inert layer and a multiplicity of such layers are contained within a tube impervious to such environment but provided with an opening into such environment. The multiplicity of such layers is driven along the length of such tube towards the opening. The interval between pulses is determined by the rate the layers are driven along the tube and the sizes of the layers. The duration of the pulse is determined by the rate of expansion or dispersion of the active layer into the environment, wherein the rate of expansion or dispersion is greater than the rate the layers are driven along the tube.Other References
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