N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes
Patent 4722928 Issued on February 2, 1988. Estimated Expiration Date: 
December 2, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 2, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2813097 3131185 3144459 3217006 3299072 3813098 InventorsAssigneeApplicationNo. 06/803222 filed on 12/02/1985US Classes:514/282One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)ExaminersPrimary: Friedman, Stanley J.International ClassesC07D 221/28 (20060101)C07D 221/00 (20060101) C07D 489/00 (20060101) C07D 489/08 (20060101) AbstractN-oxide prodrug derivatives of 3-hydroxy morphinan and partial morphinan analgesics, agonist-antagonists, and narcotic antagonists are useful therapeutic entities which provide enhanced bioavailability of 3-hydroxy morphinans and partial morphinans from orally administered dosage forms.Other References
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