Patent ReferencesAminothiazoles 2-Guanidino-4-heteroarylthiazoles Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents Patent #: 4560690 InventorsAssigneeApplicationNo. 06/799989 filed on 11/20/1985US Classes:514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/254.02, The additional five-membered hetero ring also has chalcogen as a ring member514/326, The additional ring is a hetero ring514/370, Nitrogen bonded directly to ring carbon of the thiazole ring514/371, C=X bonded directly to the nitrogen which is bonded directly to the thiazole ring (X is chalcogen)544/133, The five-membered hetero ring has at least sulfur and nitrogen as ring hetero atoms544/333, Additional hetero ring which is unsaturated544/367, Ring chalcogen in the five-membered hetero ring546/209, Ring sulfur or ring oxygen in the additional hetero ring546/270.7, Nitrogen attached directly to the 1,3-thiazole ring by nonionic bonding548/193, Chalcogen attached indirectly to the thiazole ring by nonionic bonding548/194, The chalcogen, X, is in a -C(=X)- group548/195The -C(=X)- group is bonded directly to the nitrogenExaminersPrimary: Gerstl, RobertAttorney, Agent or FirmInternational ClassesC07D 417/00 (20060101)C07D 417/04 (20060101) C07D 333/38 (20060101) C07D 333/22 (20060101) C07D 417/14 (20060101) C07D 333/00 (20060101) Foreign Application Priority Data1984-11-22 WOAbstractThienylthiazole compounds of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein: R is amino, guanidino, alkylamino, alkenylamino, unsubstituted or optionally substituted phenylamino or acylamino;A is amino, alkylamino, cyclic amino, alkanoylamino, a group of the formula: ##STR2## wherein each symbol is as defined in claim 1; Z is hydrogen or halogen; andm is 0 or 1 to 4,are useful in the treatment of peptic ulcer, acute or chronic gastritis, acute damage of gastric mucous membrane, dimentia and anxiety.Other References
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