U.S. patents available from 1976 to present.
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Compound 2-iodo-2'-deoxyadenosine

Patent 4719295 Issued on January 12, 1988. Estimated Expiration Date: Icon_subject June 27, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3201389

3337529

Inventors

Application

No. 06/879215 filed on 06/27/1986

US Classes:

536/27.7, Chalcogen, halogen, or benzene bonded directly to carbon of the purine ring system (e.g., isoguanosine, 2-fluoroadenosine, etc.)536/26.7, The N-hetero ring is part of a bicyclic ring system536/27.21The five-membered N-hetero ring is 1,3-diazole, which may be hydrogenated (e.g., 6-chloropurine nucleoside, nebularin, etc.)

Examiners

Primary: Brown, J. Travis
Assistant: Crane, L. Eric

Attorney, Agent or Firm

International Classes

C07H 19/20 (20060101)
C07H 19/00 (20060101)

Abstract

Nucleotide and nucleoside compounds are provided, namely 2-halo-2'-deoxyadenosine 5'-phosphate compounds (I) especially as the monosodium and disodium salt, and 2-iodo-2'-deoxyadenosine (II); as well as a method for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds of the invention have pharmacological properties and are useful antimicrobial agents, antiviral agents, and antileukemic agents. ##STR1##

Other References

  • Carson et al., I, Proc. Nat. Acad. Sci. USA, vol. 77(11), pp. 6865-6869, 1980
  • Carson et al., II, Blood, vol. 62(4), pp. 737-743, 1983
  • Huang et al, Chem. Abstr., 100:210318u, Jun. 18, 1984
  • Bennett et al, Chem. Abstr., 103:31970r, Aug. 5, 1985
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