U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Human stem cells

Patent 4714680 Issued on December 22, 1987. Estimated Expiration Date: Icon_subject December 22, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Assignee

Application

No. 06/670740 filed on 02/06/1984

US Classes:

435/347, Two or more cell types, per se, in co-culture435/372Blood, lymphatic, or bone marrow origin or derivative

Examiners

Primary: Wiseman, Thomas G.
Assistant: Weimar, Elizabeth C.

Attorney, Agent or Firm

International Classes

A61K 35/28 (20060101)
A61K 35/28 (20060101)
C07K 16/18 (20060101)
C07K 16/18 (20060101)
C07K 16/28 (20060101)
C07K 16/28 (20060101)

Abstract

Monoclonal antibodies that recognize a stage-specific antigen on immature human marrow cells are provided. These antibodies are useful in methods of isolating cell suspensions from human blood and marrow that can be employed in bone marrow transplantation. Cell suspensions containing human pluripotent lympho-hematopoietic stem cells are also provided, as well as theraputic methods employing the cell suspensions.

Other References

  • Strauss et al., `MY-10, A Human Hematopoietic Progenitor Cell Surface Antigen Identified by a Monoclonal Antibody`; Experimental Hematology (Lawrence), II (Suppl. 14); 1983, p. 205
  • Bodger et al.; `Surface Antigenic Determinants on Human Pluripotent and Unipotent Hematopoietic Progenitor Cells`; Blood, vol. 61, No. 5; May, 1983, pp. 1006-1010
  • Bodger et al., `A Monoclonal Antibody Specific for Immature Human Hematopoietic Cells and T Lineage Cells`; J. Immunology, vol. 127, No. 6, Dec. 1981; pp. 2269-2274
  • Civin, Strauss et al., Blood 60(5):95a (Abstract) (1982)
  • Civin, Vaughan et al., "Cell Surface Antigens of Human Myeloid Cells," (1982) Exp. Hematol. 10:129 (Abstract)
  • Civin, Brovall et al., Hybridoma 1:125a, (1983), presented Feb. 8, 1983, abstracts available Feb. 6, 1983
  • Brovall, Shaper, Civin et al., Exp. Hematol. II (Supp.):199 (1983), presented Jul. 14, 1983, abstract available Jul. 10, 1983
  • Civin, Vaughan et al., Exp. Hematol. II (Supp.):84, (1983), presented Jul. 12, 1983, abstract available Jul. 10, 1983
  • Strauss & Civin, Exp. Hematol, II:205 (1983), presented Jul. 14, 1983, abstracts available Jul. 10, 1983
  • Strauss & LaRusa and Civin, I.S.E.H. Abstract (1984)
  • Leary, Ogawa, Civin et al., I.S.E.H. Abstract (1984)
  • Civin et al., J. Immunology, (1984), vol. 13, 157-165
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