Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor
Patent 4710504 Issued on December 1, 1987. Estimated Expiration Date: 
April 4, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 4, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 06/848262 filed on 04/04/1986US Classes:514/267, Tricyclo ring system having 1,3-diazine as one of the cyclos514/210.02, Chalcogen double bonded directly to a ring carbon of the four-membered hetero ring which is adjacent to the ring nitrogen514/219, Polycyclo ring system having the seven-membered hetero ring as one of the cyclos514/228.8, Hetero ring is six-membered and includes at least nitrogen and oxygen as ring hetero atoms (e.g., monocyclic 1,2- and 1,3-oxazines, etc.)514/230.8, Chalcogen bonded directly to ring carbon of 1,4-oxazine ring514/233.2, Ring nitrogen shared by two of the cyclos514/248, Polycyclo ring system having a 1,2- or 1,4-diazine as one of the cyclos514/250, At least three rings in the polycyclo ring system514/257, Polycyclo ring system having 1,3-diazine as one of the cyclos514/278, Spiro ring system540/203, Polycyclo ring system containing the hetero ring as one of the cyclos540/353, Double bond between ring members of the five-membered hetero ring540/492, Plural nitrogens in the hetero ring540/493, Tetracyclo ring system having the hetero ring as one of the cyclos544/231, Spiro diazine544/71, Spiro oxazine546/18Polycyclo ring system having the six-membered hetero ring as one of the cyclosExaminersPrimary: Jiles, Henry R.Assistant: Mullins, J. G. Attorney, Agent or FirmInternational ClassesC07D 513/00 (20060101)C07D 498/22 (20060101) C07D 513/22 (20060101) C07D 471/00 (20060101) C07D 471/20 (20060101) C07D 498/00 (20060101) C07D 495/22 (20060101) C07D 495/00 (20060101) C07D 491/22 (20060101) C07D 491/00 (20060101) AbstractSubstituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective 댒 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility. |
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