Monoclonal antibody for human hematopoietic glycoproteins and method
Patent 4710457 Issued on December 1, 1987. Estimated Expiration Date: 
December 1, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
December 1, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsApplicationNo. 06/509201 filed on 06/29/1983US Classes:435/7.24, Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)424/153.1, Hematopoietic cell424/154.1, T lymphocytic cell (e.g., T cell, thymocyte, etc.)435/43, Preparing compound having a 1-thia-4-aza-bicyclo (3.2.0) heptane ring system (e.g., penicillin, etc.)435/70.21, Producing monoclonal antibody435/948, Using viruses or cell lines530/388.7, Binds hematopoietic cell or component or product thereof (e.g., erythrocyte granulocyte, macrophage, monocyte, platelet, myelogenous leukemia cell, bone marrow stem cell, granulocytic cell-surface antigen, hemoglobin, thrombospondin, glycophorin, etc.)530/388.73, Binds lymphocytic or lymphocytic-like cell or component or product thereof (e.g., B cell, B-lineage bone marrow cell, null cell, natural killer cell, B-lymphoblastoid cell, B-lineage acute lymphoblastic leukemia cell, B-lymphocytic cell-surface antigen, etc.)530/388.75Binds T-lymphocytic cell or component or product thereof (e.g., T cell, thymocyte, T-lineage bone marrow cell, T-lymphoblastoid cell, T-lineage acute lymphoblastic leukemia cell, T-lymphocytic cell-surface antigen, etc.)ExaminersPrimary: Nucker, Christine M.Attorney, Agent or FirmInternational ClassesC07K 16/18 (20060101)C07K 16/28 (20060101) C07K 16/30 (20060101) A61K 38/00 (20060101) AbstractThis invention concerns a new monoclonal antibody (mAb) 4C, recognizing a specific antigen, Leu 200, found in human hematopoietic tissues. The monoclonal antibody precipitates a series of glycoproteins (Leu 200) with a molecular weight range of about 190,000 to 230,000 from both T- and B-cell lines. The series of glycoproteins resolves into four discrete glycoprotein bands, the distribution of which varies according to the cell lines. Bands 3 and 4 predominate in a majority of T-cells whereas band 2 predominates in B cells. Thus, a Leu 200 antigen subset distribution is possible with mAb 4C. Bands 1, 2, 3, 4 have apparent molecular weights of 230K, 215K, 205K, and 190K respectively, with differences in their carbohydrate moieties. mAb 4C is a IgG sub two a, kappa immunoglobulin. 4C has potential use in leukemia, hematopoietic cell differentiation and transplantation diagnoses and therapy.Other References
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