U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Process for the continuous production of L-carnitine

Patent 4708936 Issued on November 24, 1987. Estimated Expiration Date: Icon_subject March 29, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Process for enzymatically producing L-carnitine Patent #: 4371618
Issued on: 02/01/1983
Inventor: Cavazza

Inventors

Assignee

Application

No. 06/717546 filed on 03/29/1985

US Classes:

435/128, Preparing nitrogen-containing organic compound435/106, Preparing alpha or beta amino acid or substituted amino acid or salts thereof435/308.1, Means for separation or recovery of a microorganism from culture media435/824, Achromobacter435/825Actinomadura

Examiners

Primary: Warren, Charles F.
Assistant: Hanley, Elizabeth A.

Attorney, Agent or Firm

International Class

C12P 13/00 (20060101)

Foreign Application Priority Data

1985-02-27 CH

Abstract

Process for the continuous production of L-carnitine by the microbiological method. A microorganism of the strain DSM No. 3225 (HK 1331b) type is cultivated in a bioreactor with crotonobetaine and/or γ-butyrobetaine in the presence of a growth substrate. The culture fluid passes outside of the bioreactor in a circulation in which a separation of the cell is carried out. A quantity of cell-free solution, which is as large as the amount fed to the bioreactor as a substrate, is withdrawn from the bioreactor. The L-carnitine is separated from the cell-free solution.

Other References

  • Ornston et al., Biochemical and Biophysical Research Communications, vol. 36, No. 1, (1969), pp. 179-184
  • Perry's Chemical Engineers Handbook, 6th Edition, (1984), pp. 27-7
  • J. H. Miller, "Experiments in Molecular Genetics", Cold Spring Laboratory, (1972), pp. 121 to 143, Experiments 13 through 17
  • P. Gerhardt et al., (eds.), Manual of Methods for General Bacteriology, Am. Soc. for Microbiology, (1981), pp. 222 to 242
  • Kulla et al., Arch. Microbiol. 135, 1 (1983), pp. 1 to 7
  • J. P. Vandecasteele, Appl. Environ, Microbiol. 39, pp. 327 to 334, (1980)
  • Lindstedt et al., Biochemistry 6, pp. 1262-1270 (1967)
  • Lindstedt et al., Biochemistry 16, pp. 2181-2188 (1977)
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