Process for enzymatically producing L-carnitine Patent #: 4371618
ApplicationNo. 06/717546 filed on 03/29/1985
US Classes:435/128, Preparing nitrogen-containing organic compound435/106, Preparing alpha or beta amino acid or substituted amino acid or salts thereof435/308.1, Means for separation or recovery of a microorganism from culture media435/824, Achromobacter435/825Actinomadura
ExaminersPrimary: Warren, Charles F.
Assistant: Hanley, Elizabeth A.
Attorney, Agent or Firm
International ClassC12P 13/00 (20060101)
Foreign Application Priority Data1985-02-27 CH
AbstractProcess for the continuous production of L-carnitine by the microbiological method. A microorganism of the strain DSM No. 3225 (HK 1331b) type is cultivated in a bioreactor with crotonobetaine and/or γ-butyrobetaine in the presence of a growth substrate. The culture fluid passes outside of the bioreactor in a circulation in which a separation of the cell is carried out. A quantity of cell-free solution, which is as large as the amount fed to the bioreactor as a substrate, is withdrawn from the bioreactor. The L-carnitine is separated from the cell-free solution.