Transdermal therapeutic system having improved delivery characteristics
November 3, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3598122 3742951 3813466 3923939 Drug-delivery device comprising certain polymeric materials for controlled release of drug Device consisting of copolymer having acetoxy groups for delivering drugs Therapeutic system for administering clonidine transdermally Biosynthetic polymeric compositions Method and therapeutic system for administering scopolamine transdermally Therapeutic system for administering drugs to the skin InventorsApplicationNo. 06/626095 filed on 06/29/1984US Classes:424/449, Transdermal or percutaneous424/448, Pressure sensitive adhesive means514/953, SHAPED FORMS ADAPTED FOR NONINGESTIBLE USE OTHER THAN SUPPOSITORY TYPE (E.G., FILMS, INSERTS, ETC.)514/965Discrete particles in supporting matrixExaminersPrimary: Griffin, Ronald W.Attorney, Agent or FirmInternational ClassA61K 9/70 (20060101)AbstractA transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, Cr therein which is lower than the initial solubility Co of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix Dm and the portion of reinforcing means Dr and the solubilities is given by the relationship: Dr ⋅Cr <Dm ⋅Co. In operation the agent dissolved in the reinforcing means acts as a secondary reservoir improving the release characteristics of the system. Specific embodiments of the invention are particularly adapted for scrotal and labial delivery of drugs such as testosterone and progesterone.Other References
| |
