U.S. patents available from 1976 to present.
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Method and compositions for controlling pain, depression and sedation

Patent 4698342 Issued on October 6, 1987. Estimated Expiration Date: Icon_subject May 20, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventor

Assignee

Application

No. 06/830717 filed on 05/20/1986

US Classes:

514/253.04, Bicyclo ring having the additional six-membered nitrogen hetero ring as one of the cyclos514/277, Hetero ring is six-membered consisting of one nitrogen and five carbon atoms514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/419, C=X bonded directly or indirectly by an acyclic carbon or carbon chain to ring carbon of the five-membered hetero ring (e.g., tryptophan, etc.) (X is chalcogen)514/479With an additional active ingredient

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Class

A61K 31/495 (20060101)

Abstract

Compositions are disclosed for controlling pain, depression, and sedation. The compositions comprise a serotonin precursor such as L-tryptophan or L-5-hydroxytryptophan in combination with a serotonin-specific reuptake inhibitor such as trazodone. In a preferred embodiment, the compositions are coadministered with a narcotic, the composition substantially potentiating the analgesic effect of the narcotic.

Other References

  • Chem. Abst. (94)-25034t (1981)
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