Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
April 4, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3759890 Carrier-bound protein prepared by reacting the protein with an acylating or alkylating compound having a carrier-bonding group and reacting the product with a carrier Reactive derivatives of HS-group-containing polymers Chemically modified endotoxin immunizing agent Peptide macromolecular complexes Immunogenic polysaccharide-protein conjugates Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them Coupled H. influenzae type B vaccine Patent #: 4459286 InventorsAssigneeApplicationNo. 06/719678 filed on 04/04/1985US Classes:424/197.11, Conjugate or complex includes bacterium or component thereof or substance produced by said bacterium424/256.1, Hemophilus (e.g., Hemophilus influenzae, Hemophilus gallinarum, Hemophilus pleuropnemoniae, etc.)424/831, INVOLVING CAPSULAR POLYSACCHARIDE OF BACTERIUM (E.G., POLYRIBOSYL RIBITOL PHOSPHATE (PRP), ETC.)435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate530/395, Glycoprotein, e.g., mucins proteoglycans, etc.530/402, Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.530/403, Protein is identified as an antigen, e.g., immunogenic carriers, etc.530/404, Sulfur containing reactant530/405, Nitrogen containing reactant530/406, Oxygen containing reactant536/123, Plural diverse saccharides containing (e.g., hetero polysaccharides, etc.)536/123.1, Polysaccharides536/34, Phosphorus containing acid536/55.1PolysaccharidesExaminersPrimary: Kight, JohnAssistant: Draper, Garnette D. Attorney, Agent or FirmInternational ClassesA61K 39/385 (20060101)A61K 39/39 (20060101) A61K 47/48 (20060101) C07K 17/06 (20060101) C07K 17/10 (20060101) C07K 17/00 (20060101) G01N 33/531 (20060101) G01N 33/569 (20060101) AbstractCovalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.Other References
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