U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Microphase separated hydrogels for controlled release of bioactive materials

Patent 4693887 Issued on September 15, 1987. Estimated Expiration Date: Icon_subject September 15, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Chemically joined, phase separated self-cured hydrophilic thermoplastic graft copolymers and their preparation
Patent #: 4085168
Issued on: 04/18/1978
Inventor: Milkovich, et al.

Water-insoluble hydrophilic copolymers
Patent #: 4277582
Issued on: 07/07/1981
Inventor: Mueller ,   et al.

Water absorptive composition Patent #: 4300820
Issued on: 11/17/1981
Inventor: Shah

Inventor

Assignee

Application

No. 06/606794 filed on 05/03/1984

US Classes:

424/486, Synthetic polymer514/772.5Heterocyclic monomer

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

International Classes

A61K 9/20 (20060101)
A61K 47/32 (20060101)
C08L 39/06 (20060101)
C08L 57/00 (20060101)
C08L 39/00 (20060101)

Abstract

Novel hydrogel compositions, comprised of a blend of two thermoplastic uncrosslinked polymers, one of which is hydrophobic, and the other hydrophilic, and having a microphase separated morphology are described. These hydrogel compositions are useful as devices for controlling the release rate of bioactive agents, such as therapeutic drugs, antimicrobials, contraceptive agents, or the like, in a biological environment. Depending upon the chemical nature of the agent to be released, its rate of release can be controlled by appropriate selection of the polymeric components of the blend and their relative ratios.

Other References

  • Hasaka et al
  • Okano et al
  • Nakashima et al
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