Local delivery of chemotherapeutic agents for the treatment of periodontal disease
Patent 4685883 Issued on August 11, 1987. Estimated Expiration Date: July 26, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
433/215, METHOD OR MATERIAL FOR TESTING, TREATING, RESTORING, OR REMOVING NATURAL TEETH424/435, Mouth433/136, Having absorption means or means to isolate tooth or mouth from adjacent area (e.g., bib, dam, etc.)433/80Having intra-oral dispensing means
A method for local delivery of chemotherapeutic agent (12) to a localized site in the mouth is disclosed. The method of delivery includes displacement or reflection of gingival tissues (20) from the tooth, in the area to be treated, to facilitate access to the periodontal lesion (16). A biodegradable, time-release microsphere (10) capsulating the chemotherapeutic agent is next positioned in the lesion (16). Accordingly, localized delivery of chemotherapeutic agent (12) continuously over a predetermined period of time is provided.
Other References
"Timed-Release Anesthetic Developed", The Washington Post, Mar. 6, 1985
Goodson, J. M., Haffajee, A. and Socransky, S. S.: Periodontal Therapy by Local Delivery of Tetracycline. J. Clin. Periodontal 6:83, 1979
Lindhe, J. et al.: Local Tetracycline Delivery Using Hollow Fiber Devices in Periodontal Therapy., J. Clin. Periodontal, 6:141, 1979
Goodson, J. M. et al.: Monolithic Tetracycline-Containing Fibers for Controlled Delivery to Periodontal Pockets., J. Clin. Periodontal 54:575, Oct. 1983
The Effect of Long-Term Low-Dose Tetracycline Therapy on the Subgingival Microflora in refractory Adult Periodontitis, K. S. Kornman et al., Journal of Periodontology, 1982:53:604-610
The Development and in Vitro Evaluation of Acrylic Strips and Dialysis Tubing for Local Drug Delivery, M. Addy et al., Journal of Periodontology, 1982:53:693-699
Tetracycline and its Derivatives Strongly Bind to and are released from the Tooth Surface in Active Form, P. J. Baker et al., Journal of Periodontology 1983:54:580-585
Subgingival Metronidazole in Acrylic Resin vs. Chlorhexidine Irrigation in the Control of Chronic Periodontitis, F. I. S. Yeung et al., Journal of Periodontology, 1983:54:651-657
Subgingival Metronidazole in Dialysis Tubing and Subgingival Chlorhexidine Irrigation in the Control of Chronic Inflammatory Periodontal Disease, W. Z. A. Wan Yusof et al., Journal of R. Clinical Periodontology, 1984:11:166-175
Comparison of the Immediate Effects on the Subgingival Microflora of Acrylic Strips Containing 40% Chlorhexidine Metronidazole or Tetracycline, M. Addy et al., Journal of Clinical Periodontology, 1984:11:379-386
Simple Bacteriological Methods to Assess Changes in Subbingival Microflora Produced by Metronidazole-Containing Acrylic Strips Placed into Periodontal Pockets, M. Addy et al., Journal of Clinical Periodontology, 1984:11:467-474
Slow Release Metronidazole and a Simplified Mechanical Oral Hygiene Regimen in the Control of Chronic Periodontitis, H. N. Newman et al., Journal of Clinical Periodontology, 1984:11:576-582
Clinical Responses Following Periodontal Treatment by Local Drug Delivery, J. M. Goodson et al., Journal of Periodontology, Supplement 1985:81-87
Tetracyclines Inhibit Tissue collagenases: Effects of Ingested Low-Dose and Local Delivery Systems, L. M. Golub et al., Journal of Periodontology, Supplement, 1985:93-97
Freeze-Dried Bone Allografts Combined with Tetracycline in the Treatment of Juvenile Periodontitis, Thomas W. Mabry et al., Journal of Periodontology, 1985:56:74-81
Periodontal Disease Treatment by Local Drug Delivery, J. M. Goodson, Journal of Periodontology, 1985:56:265-272
Clinical and Microbiological Effects of Sustained Release chlorhexidine in Periodontal Pockets, A. Stabholz et al., Journal of Clinical Periodontology, 1986:13:783-788
Gum Disease Alleviated by Pellets, Patricia R. Raber, Dentistry Today, vol. 5, No. 5, Jun. 1986
Kakehashi, S. and Parakkal, P. F.: Proceedings From the State of the Art Workshop on Surgical Therapy for Periodontitis., J. Periodontal 53:475, 1982
Genco, R. J.: Antibiotics in the Treatment of Human Periodontal Diseases., J. Periodontal 52:545, 1981
July 26, 2005. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
