U.S. patents available from 1976 to present.
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Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA

Patent 4681840 Issued on July 21, 1987. Estimated Expiration Date: Icon_subject July 21, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Sensitive tests for malignancies based on DNA detection
Patent #: 4490472
Issued on: 12/25/1984
Inventor: Gottlieb

Characterization of oncogenes and assays based thereon Patent #: 4535058
Issued on: 08/13/1985
Inventor: Weinberg ,   et al.

Inventors

Assignee

Application

No. 06/571911 filed on 01/18/1984

US Classes:

435/6, Involving nucleic acid435/91.53, Involving a hydrolase (3.)436/504, Radioactive label536/23.5, Encodes an animal polypeptide536/24.31, Probes for detection of animal nucleotide sequences536/25.32Labels or markers utilized (e.g., radiotracer, affinity, fluoroescent, phosphorescent, markers, etc.)

Examiners

Primary: Marantz, Sidney

Attorney, Agent or Firm

International Class

C12Q 1/68 (20060101)

Abstract

A single-stranded deoxyribonucleic acid molecule having a length of less than about 25 kb comprises at least three distinct nucleotide sequences which are the sites for incorporation into a chromosome of a deoxyribonucleic acid molecule encoding a deleterious gene. Deoxyribonucleic acid probes have been prepared from such molecules and are useful as hybridization probes for detecting chromosomal deoxyribonucleic acid which has a deoxyribonucleic acid molecule encoding a deleterious gene, i.e. oncogene, incorporated therein.A single-stranded deoxyribonucleic acid molecule derived from human chromosome 22 which is about 5.8 kb in length contains sites for incorporation of a deoxyribonucleic acid molecule encoding the oncogene c-abl derived from human chromosome 9. Deoxyribonucleic acid probes have been prepared from this molecule and used to detect the abnormal Philadelphia chromosome and chronic myelocytic leukemia.

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