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US Patent 4678666 - Topical anti-inflammatory compositions

US Patent Issued on July 7, 1987
Estimated Patent Expiration Date: Icon_subject August 14, 2006Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A novel formulation of piroxicam for dermatological administration is disclosed. Pharmaceutical compositions containing piroxicam, lower alkanols, water, carboxyvinyl polymer, polyhydric alcohols, alkanolamines and optionally film-forming agents are prepared, said compositions having a pH of from about 6.5 to about 9.0. The novel formulation is characterized by excellent applicability on the skin, skin-permeability and good stability. The novel formulation, which is in gel ointment form, is as effective as orally administered peroxicam and is well suited for topical administration through skin for the treatment of various types of inflammatory conditions.

Other References

  • P Schiantarelli et al., "Anti-inflammatory Activity and Bioavailability of Percutaneous Piroxicam", Arzneim-Forsch./Drug Res., 32(I), No. 3, p. 230 (1982)
  • Chemical Abstracts, vol. 95, p. 103322x (1981)

Inventors

Application

No. 06/896370 filed on 08/14/1986

US Classes:

514/224.2, Polycyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., 1,3- and 1,4- benzothiazines, etc.)424/78.05Anti-inflammatory or anti-irritant (e.g., anti-arthritic, etc.)

Examiners

Primary: Friedman, Stanley J.

Attorney, Agent or Firm

US Patent References

3591584, 4434164Crystalline benzothiazine dioxide salts
Issued on: 02/28/1984
Inventor: Lombardino

International Classes

A61K 9/70 (20060101)
A61K 47/38 (20060101)
A61K 47/10 (20060101)
A61K 47/32 (20060101)
A61K 47/18 (20060101)
A61K 47/16 (20060101)
A61K 31/54 (20060101)

Foreign Application Priority Data

1982-07-13 JP

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