Patent References 3495001 3556803 3594472 3773922 Pharmaceutical composition Rapid dissolving effervescent granules Denture cleansing tablet and process for making Alkaline analgesic capsule Capsule product containing high dosage of aspirin in powder or granulated form and alkaline tablet or pellet comprising magnesium carbonate, calcium carbonate and a magnesium dry component Cleansing tablets for tooth prostheses InventorsApplicationNo. 06/880081 filed on 06/30/1986US Classes:424/44, Gas produced in situ by chemical reaction424/466, Effervescent424/646, Iron, cobalt, nickel, vanadium, molybdenum, or palladium424/687, Calcium carbonate424/717, Bicarbonate514/474, Ascorbic acid or derivative (e.g., vitamin C, etc.)514/819ANTACID, ORALExaminersPrimary: Griffin, Ronald W.Attorney, Agent or FirmInternational ClassesA23L 2/40 (20060101)A61K 33/10 (20060101) A61K 33/06 (20060101) A61K 9/46 (20060101) Foreign Application Priority Data1983-09-28 ATAbstractEffervescent granulates, particularly for the manufacture of effervescent tablets, comprising at least one solid, crystalline edible organic acid and at least one carbonate which releases carbon dioxide upon reaction with the organic acid, the acid crystals comprising a coating which contains calcium carbonate adhering to the surface of the acid crystals by means of a bonding layer formed by a reaction at the interface with the crystal of a calcium carbonate coating material. The coating is built up in multi-layers and includes at least two carbonate layers, the layer which is bonded essentially to the acid crystal being composed of calcium carbonate with the succeeding layers adhering to the carbonate layer by means of a bonding layer formed by reaction of the acid and the carbonate. The invention also deals with methods of manufacture as well as fields of use for the new effervescent granulates. | |