Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
Patent 4673679 Issued on June 16, 1987. Estimated Expiration Date: 
May 14, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 14, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod of administering narcotic antagonists and analgesics and novel dosage forms containing same Analgesic compositions Patent #: 4582835 InventorsAssigneeApplicationNo. 06/863045 filed on 05/14/1986US Classes:514/282, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)514/812, Narcotic514/969, OINTMENT OR SALVE BASE546/39, Two of the cyclos share at least three ring members (e.g., etheno morphides, etc.)546/44, One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)546/45, Nitrogen or divalent chalcogen double bonded directly to carbocyclic ring of the pentacyclo ring system (e.g., morphinones, etc.)546/74Two of the cyclos share at least three ring members (e.g., morphinans, etc.)ExaminersPrimary: Friedman, Stanley J.International ClassesA61K 9/00 (20060101)A61K 31/485 (20060101) AbstractAliphatic, aromatic, carbonate, carbamate, or sulfonate ester prodrugs of 3-hydroxymorphinans lack the bitter taste of the parent compounds and provide enhanced bioavailability of 3-hydroxymorphinans from buccal, nasal, and sublingual dosage forms. |
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