Patent 4671295 Issued on June 9, 1987. Estimated Expiration Date: November 11, 2006. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Blood flow in the aorta and pulmonary artery of a mammal, most typically a human, is measured volumetrically by a non-invasive, ultrasound method and apparatus. The method comprises placing a piezoelectric ultrasound transducer in the trachea in great proximity to the aorta or pulmonary artery by passage through the oral or nasal cavity past the epiglottis and into the trachea or by passage through the surgical opening into the trachea in the case of patients who have had a tracheotomy. Ultrasound waves are transmitted toward the path of flow of blood in the artery. Reflected waves are received. The average Doppler frequency difference between transmitted and received waves is measured. The cross-sectional size of the artery is measured. Blood flow rate is determined from the measurements. The apparatus comprises a tracheal tube or probe with one or two transducers mounted at one end the tube. The transducer(s) is (are) disposed to transmit ultrasound in selected directions. Electrical conductors extend from the transducers the length of the probe.
Other References
Jethwa et al, "Blood Flow Measurements Using Ultrasonic Pulsed Random Signal Doppler System", IEEE Transactions on Sonics and Ultrasonics I-11, Jan. 1975
Huntsman et al, "Transcutaneous Determination of Aortic Blood-Flow", American Heart Journal, vol. 89, No. 5, 609-612, May 1975
Kohanna et al, "Monitoring of Cardiac Output by Thermodilution After Open Heart Surgery", Journal of Thoracic and Cardiovascular Surgery, vol. 73, No. 3, pp. 451-457, 3/77
Darsee et al, "Transcutaneous Doppler Method of Measuring Cardiac Output", American Journal of Cardiology, vol. 46, pp. 613-618, Oct. 1980
Heneghan et al, "Non-Invasive Measurement of Cardiac Output During Anaesthesia", British Journal of Anaesthesia, vol. 53, pp. 351-355, 1981
Hartley et al, "An Ultrasonic Pulsed Doppler System for Measuring Blood Flow in Small Vessels", Journal of Applied Physiology, vol. 37, No. 4, Oct. 1974
Huntsman et al, "Non-Invasive Doppler Determination of Cardiac Output in Man", Circulation, vol. 67, No. 3, Mar. 1983, pp. 593-602
Keagy et al, "A Removeable Extraluminal Doppler Probe for Continuous Monitoring of Changes in Cardiac Output", Journal of Ultrasound Medicine, 2:357-362, Aug. 1983
Baker, "Pulsed Ultrasonic Doppler Blood-Flow Sensing", IEEE Transactions on Sonics and Ultrasonics, vol. SU-17, No. 3, Jul. 1970, pp. 170-184
Duck et al, "An Esophageal Doppler Probe for Aortic Flow Velocity Monitoring", Ultrasound in Med. & Biol., vol. 1, No. 3, pp. 233-241, Aug. 1974
Olson et al, "A Nondestructive Ultrasonic Technique to Measure Diameter and Blood Flow in Arteries", IEEE Transactions on Biomedical Engineering, vol. BME-21, No. 2, pp. 168-171, Mar. 1974
Histand et al, "Ultrasonic Pulsed Doppler Transoesophageal Measurement of Aortic Haemodynamics in Humans", Ultrasonics, Sep. 1979
Wells et al, "Ultrasonic Transesophageal Measurement of Cardiac Output", 1978 Advances in Bioengineering, San Francisco, Calif., (Dec. 10-15, 1978), pp. 121-123
Martin et al, "An Ultrasonic Catheter for Intravascular Measurement of Blood Flow", IEEE Transactions on Sonics and Ultrasonics, vol. SU-27, No. 6, Nov. 1980, pp. 277-286