7-amino-1-cyclopropyl-4-oxo-1, 4-dihydro-quinoline-and naphthyridine-3-carboxylic acids and antibacterial agents containing these compounds

Patent 4670444 Issued on June 2, 1987. Estimated Expiration Date:

June 2, 2004. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3849421

Piperazinyl derivatives of quinoline carboxylic acids
Patent #: 4146719
Issued on: 03/27/1979
Inventor: Irikura

Process for the preparation of 4-pyridone-3-carboxylic acids and/or derivatives thereof
Patent #: 4284629
Issued on: 08/18/1981
Inventor: Grohe , et al.

1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
Patent #: 4292317
Issued on: 09/29/1981
Inventor: Pesson

Process for the preparation of quinoline carboxylic acid derivatives
Patent #: 4472579
Issued on: 09/18/1984
Inventor: Irikura , et al.

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid and metal salts thereof useful in burn therapy
Patent #: 4522819
Issued on: 06/11/1985
Inventor: Fox, Jr. , et al.

2-Amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido[2,3-d]-pyrimidin e-6-carboxylic acid compounds Patent #: 4556709
Issued on: 12/03/1985
Inventor: Grohe , et al.

Inventors

Application

No. 06/614923 filed on 05/29/1984

US Classes:

514/300, Plural hetero atoms in the bicyclo ring system514/230.8, Chalcogen bonded directly to ring carbon of 1,4-oxazine ring514/234.5, Plural ring nitrogens in the bicyclo ring system514/235.2, Ring nitrogen in the bicyclo ring system514/252.18, Additional six-membered hetero ring consisting of five ring carbons and one ring nitrogen attached directly or indirectly to the 1,3-diazine by nonionic bonding514/253.04, Bicyclo ring having the additional six-membered nitrogen hetero ring as one of the cyclos514/253.08, Having -C(=X)-, wherein X is chalcogen, bonded directly to carbon of the hetero ring of the quinoline ring system514/312, Chalcogen attached directly to the six-membered hetero ring by nonionic bonding544/127, The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system544/128, Quinoline or isoquinoline (including hydrogenated)544/295, Plural diazine rings544/362, The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system544/363, Quinoline or isoquinoline (including hydrogenated)546/123, Chalcogen and -C(=X)-, wherein X is chalcogen, bonded directly to ring carbons of the bicyclo ring system (e.g., 4-oxo-naphthyridine -3-carboxylic acid, etc.)546/156Having -C(=X)-, wherein X is chalcogen, bonded directly to the six-membered hetero ring

Examiners

Primary: Hollrah, Glennon H.
Assistant: Turnipseed, James H.

Attorney, Agent or Firm

Sprung Horn Kramer & Woods

International Classes

C07D 215/00 (20060101)
C07D 215/00 (20060101)
C07D 215/56 (20060101)
C07D 215/56 (20060101)
C07D 471/04 (20060101)
C07D 471/04 (20060101)
C07D 471/00 (20060101)
C07D 471/00 (20060101)

Foreign Application Priority Data

1980-09-03 DE

Abstract

The invention relates to 7-amino-1-cyclo-propyl-4-oxo-1, 4-dihydro-naphthyridine (or quinoline)-3-carboxylic acids of Formula I as defined in the specification. Also included in the invention is a process for the preparation of said compounds of Formula I and Ia. Further, the invention includes compositions containing the compounds of Formula I or Ia and the use of said compounds and compositions as antibacterial agents.